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- W2913249938 abstract "The postsynaptic density (PSD) is an electron dense, semi-membrane bound compartment that lies beneath postsynaptic membranes. This region is densely packed with thousands of proteins that are involved in extensive interactions. During synaptic plasticity, the PSD undergoes changes in size and composition along with changes in synaptic strength that lead to long term potentiation (LTP) or depression (LTD). It is therefore essential to understand the organization principles underlying PSD assembly and rearrangement. Here, we review exciting new findings from recent in vitro reconstitution studies and propose a hypothesis that liquid–liquid phase separation mediates PSD formation and regulation. We also discuss how the properties of PSD formed via phase separation might contribute to the biological functions observed from decades of researches. Finally, we highlight unanswered questions regarding PSD organization and how in vitro reconstitution systems may help to answer these questions in the coming years." @default.
- W2913249938 created "2019-02-21" @default.
- W2913249938 creator A5021163747 @default.
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- W2913249938 creator A5063460883 @default.
- W2913249938 date "2019-08-01" @default.
- W2913249938 modified "2023-10-01" @default.
- W2913249938 title "Phase separation as a mechanism for assembling dynamic postsynaptic density signalling complexes" @default.
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- W2913249938 doi "https://doi.org/10.1016/j.conb.2018.12.001" @default.
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- W2913249938 hasPublicationYear "2019" @default.
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