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- W2913252005 abstract "The prefrontal cortex (PFC), which plays key roles in many higher cognitive processes, is a hierarchical system consisting of multi-scale organizations. Optimizing the working state at each scale is essential for PFC’s information processing. Typical optimal working states at different scales have been separately reported, including the dopamine-mediated inverted-U profile of the working memory (WM) at the system level, critical dynamics at the network level, and detailed balance of excitatory and inhibitory currents (E/I balance) at the cellular level. However, it remains unclear whether these states are scale-specific expressions of the same optimal state and, if so, what is the underlying mechanism for its regulation traversing across scales. Here, by studying a neural network model, we show that the optimal performance of WM co-occurs with the critical dynamics at the network level and the E/I balance at the level of individual neurons, suggesting the existence of a unified, multi-scale optimal state for the PFC. Importantly, such a state could be modulated by dopamine at the synaptic level through a series of U or inverted-U profiles. These results suggest that seemingly different optimal states for specific scales are multi-scale expressions of one condition regulated by dopamine. Our work suggests a cross-scale perspective to understand the PFC function and its modulation." @default.
- W2913252005 created "2019-02-21" @default.
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- W2913252005 date "2019-02-28" @default.
- W2913252005 modified "2023-10-18" @default.
- W2913252005 title "Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex" @default.
- W2913252005 cites W125710414 @default.
- W2913252005 cites W1516755758 @default.
- W2913252005 cites W1541267199 @default.
- W2913252005 cites W1892194563 @default.
- W2913252005 cites W1895591704 @default.
- W2913252005 cites W1934525866 @default.
- W2913252005 cites W1963850213 @default.
- W2913252005 cites W1966841546 @default.
- W2913252005 cites W1967590974 @default.
- W2913252005 cites W1969275478 @default.
- W2913252005 cites W1988597888 @default.
- W2913252005 cites W1992421401 @default.
- W2913252005 cites W1992645470 @default.
- W2913252005 cites W1994341528 @default.
- W2913252005 cites W1999048656 @default.
- W2913252005 cites W2004242694 @default.
- W2913252005 cites W2008284899 @default.
- W2913252005 cites W2010010320 @default.
- W2913252005 cites W2010213938 @default.
- W2913252005 cites W2012601800 @default.
- W2913252005 cites W2022851351 @default.
- W2913252005 cites W2030362416 @default.
- W2913252005 cites W2031534534 @default.
- W2913252005 cites W2036597812 @default.
- W2913252005 cites W2037735958 @default.
- W2913252005 cites W2043161845 @default.
- W2913252005 cites W2045565759 @default.
- W2913252005 cites W2046835548 @default.
- W2913252005 cites W2048260661 @default.
- W2913252005 cites W2049517487 @default.
- W2913252005 cites W2057755457 @default.
- W2913252005 cites W2064481931 @default.
- W2913252005 cites W2067012111 @default.
- W2913252005 cites W2072652550 @default.
- W2913252005 cites W2072804750 @default.
- W2913252005 cites W2073820635 @default.
- W2913252005 cites W2076208166 @default.
- W2913252005 cites W2076900079 @default.
- W2913252005 cites W2079364317 @default.
- W2913252005 cites W2079600992 @default.
- W2913252005 cites W2082352870 @default.
- W2913252005 cites W2083419496 @default.
- W2913252005 cites W2088856850 @default.
- W2913252005 cites W2089880505 @default.
- W2913252005 cites W2094134651 @default.
- W2913252005 cites W2096707172 @default.
- W2913252005 cites W2101948750 @default.
- W2913252005 cites W2102293491 @default.
- W2913252005 cites W2109105506 @default.
- W2913252005 cites W2116340390 @default.
- W2913252005 cites W2119410682 @default.
- W2913252005 cites W2120548621 @default.
- W2913252005 cites W2121345030 @default.
- W2913252005 cites W2122803078 @default.
- W2913252005 cites W2123383560 @default.
- W2913252005 cites W2132817065 @default.
- W2913252005 cites W2149013149 @default.
- W2913252005 cites W2151703285 @default.
- W2913252005 cites W2154397718 @default.
- W2913252005 cites W2155158475 @default.
- W2913252005 cites W2158098851 @default.
- W2913252005 cites W2168462263 @default.
- W2913252005 cites W2168497148 @default.
- W2913252005 cites W2168815228 @default.
- W2913252005 cites W2184833738 @default.
- W2913252005 cites W2282523187 @default.
- W2913252005 cites W2320983896 @default.
- W2913252005 cites W2557795797 @default.
- W2913252005 cites W2767454510 @default.
- W2913252005 cites W2800701562 @default.
- W2913252005 cites W2963499979 @default.
- W2913252005 cites W2964039124 @default.
- W2913252005 cites W3020825243 @default.
- W2913252005 cites W3103629061 @default.
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- W2913252005 doi "https://doi.org/10.3389/fphys.2019.00113" @default.
- W2913252005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6404637" @default.
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