FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913255668> ?p ?o ?g. }

• W2913255668 abstract "Abstract Background: Acute treatment with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (Flx), induces anxiety-like behavioral effects. The serotonin2A receptor (5-HT2A) is implicated in the modulation of anxiety-like behavior, however its contribution to the anxiogenic effects of acute Flx remains unclear. Here, we examined the role of the 5-HT2A receptor in the effects of acute Flx on anxiety-like behavior, serum corticosterone levels, neural activation and immediate early gene (IEG) expression in stress-responsive brain regions, using 5-HT2A receptor knockout (5-HT2A−/−) mice of both sexes. Methods: 5-HT2A−/− and wild-type (WT) male and female mice received a single administration of Flx or vehicle, and were examined for anxiety-like behavior, serum corticosterone levels, FBJ murine osteosarcoma viral oncogene homolog peptide (c-Fos) positive cell numbers in stress-responsive brain regions of the hypothalamus and prefrontal cortex (PFC), and PFC IEG expression. Results: The increased anxiety-like behavior and enhanced corticosterone levels evoked by acute Flx were unaltered in 5-HT2A−/− mice of both sexes. 5-HT2A−/− female mice exhibited a diminished neural activation in the hypothalamus in response to acute Flx. Further, 5-HT2A−/− male, but not female, mice displayed altered baseline expression of several IEGs (brain-derived neurotrophic factor (Bdnf), Egr2, Egr4, FBJ osteosarcoma gene (Fos), FBJ murine osteosarcoma viral oncogene homolog B (Fosb), Fos-like antigen 2 (Fosl2), Homer scaffolding protein (Homer) 1-3 (Homer1-3), Jun proto-oncogene (Jun)) in the PFC. Conclusion: Our results indicate that the increased anxiety and serum corticosterone levels evoked by acute Flx are not influenced by 5-HT2A receptor deficiency. However, the loss of function of the 5-HT2A receptor alters the degree of neural activation of the paraventricular nucleus (PVN) of the hypothalamus in response to acute Flx, and baseline expression of several IEGs in the PFC in a sexually dimorphic manner." @default.
• W2913255668 created "2019-02-21" @default.
• W2913255668 creator A5009565241 @default.
• W2913255668 creator A5013653469 @default.
• W2913255668 creator A5036348942 @default.
• W2913255668 creator A5052983587 @default.
• W2913255668 creator A5073680216 @default.
• W2913255668 date "2019-02-01" @default.
• W2913255668 modified "2023-10-09" @default.
• W2913255668 title "5-HT2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression" @default.
• W2913255668 cites W1891846574 @default.
• W2913255668 cites W1975477712 @default.
• W2913255668 cites W1986541770 @default.
• W2913255668 cites W1991639159 @default.
• W2913255668 cites W2016647678 @default.
• W2913255668 cites W2017298826 @default.
• W2913255668 cites W2024985387 @default.
• W2913255668 cites W2037364272 @default.
• W2913255668 cites W2037596036 @default.
• W2913255668 cites W2040350559 @default.
• W2913255668 cites W2062089925 @default.
• W2913255668 cites W2067210092 @default.
• W2913255668 cites W2079172254 @default.
• W2913255668 cites W2082074719 @default.
• W2913255668 cites W2084188625 @default.
• W2913255668 cites W2086861479 @default.
• W2913255668 cites W2087877032 @default.
• W2913255668 cites W2092831348 @default.
• W2913255668 cites W2102812893 @default.
• W2913255668 cites W2103625248 @default.
• W2913255668 cites W2104516271 @default.
• W2913255668 cites W2105571318 @default.
• W2913255668 cites W2128497690 @default.
• W2913255668 cites W2130400234 @default.
• W2913255668 cites W2136816138 @default.
• W2913255668 cites W2139344256 @default.
• W2913255668 cites W2140175678 @default.
• W2913255668 cites W2143649581 @default.
• W2913255668 cites W2144216102 @default.
• W2913255668 cites W2171104921 @default.
• W2913255668 cites W2224635535 @default.
• W2913255668 cites W2259604282 @default.
• W2913255668 cites W2403020376 @default.
• W2913255668 cites W2516878167 @default.
• W2913255668 cites W2616458250 @default.
• W2913255668 cites W2624177825 @default.
• W2913255668 doi "https://doi.org/10.1042/ns20180205" @default.
• W2913255668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7363295" @default.
• W2913255668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32714597" @default.
• W2913255668 hasPublicationYear "2019" @default.
• W2913255668 type Work @default.
• W2913255668 sameAs 2913255668 @default.
• W2913255668 citedByCount "1" @default.
• W2913255668 countsByYear W29132556682022 @default.
• W2913255668 crossrefType "journal-article" @default.
• W2913255668 hasAuthorship W2913255668A5009565241 @default.
• W2913255668 hasAuthorship W2913255668A5013653469 @default.
• W2913255668 hasAuthorship W2913255668A5036348942 @default.
• W2913255668 hasAuthorship W2913255668A5052983587 @default.
• W2913255668 hasAuthorship W2913255668A5073680216 @default.
• W2913255668 hasBestOaLocation W29132556681 @default.
• W2913255668 hasConcept C104317684 @default.
• W2913255668 hasConcept C121608353 @default.
• W2913255668 hasConcept C126322002 @default.
• W2913255668 hasConcept C134018914 @default.
• W2913255668 hasConcept C150194340 @default.
• W2913255668 hasConcept C170493617 @default.
• W2913255668 hasConcept C205044023 @default.
• W2913255668 hasConcept C2775864247 @default.
• W2913255668 hasConcept C2777003273 @default.
• W2913255668 hasConcept C2777099045 @default.
• W2913255668 hasConcept C2777765862 @default.
• W2913255668 hasConcept C2779555244 @default.
• W2913255668 hasConcept C2780092697 @default.
• W2913255668 hasConcept C2780352252 @default.
• W2913255668 hasConcept C2781018059 @default.
• W2913255668 hasConcept C2781093953 @default.
• W2913255668 hasConcept C29537977 @default.
• W2913255668 hasConcept C53910766 @default.
• W2913255668 hasConcept C55493867 @default.
• W2913255668 hasConcept C71315377 @default.
• W2913255668 hasConcept C71924100 @default.
• W2913255668 hasConcept C86803240 @default.
• W2913255668 hasConceptScore W2913255668C104317684 @default.
• W2913255668 hasConceptScore W2913255668C121608353 @default.
• W2913255668 hasConceptScore W2913255668C126322002 @default.
• W2913255668 hasConceptScore W2913255668C134018914 @default.
• W2913255668 hasConceptScore W2913255668C150194340 @default.
• W2913255668 hasConceptScore W2913255668C170493617 @default.
• W2913255668 hasConceptScore W2913255668C205044023 @default.
• W2913255668 hasConceptScore W2913255668C2775864247 @default.
• W2913255668 hasConceptScore W2913255668C2777003273 @default.
• W2913255668 hasConceptScore W2913255668C2777099045 @default.
• W2913255668 hasConceptScore W2913255668C2777765862 @default.
• W2913255668 hasConceptScore W2913255668C2779555244 @default.
• W2913255668 hasConceptScore W2913255668C2780092697 @default.
• W2913255668 hasConceptScore W2913255668C2780352252 @default.
• W2913255668 hasConceptScore W2913255668C2781018059 @default.
• W2913255668 hasConceptScore W2913255668C2781093953 @default.
• W2913255668 hasConceptScore W2913255668C29537977 @default.

• next