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- W2913257746 abstract "Before puberty, boys have an increased prevalence of asthma compared to girls, and boys are twice as likely to have an asthma exacerbation requiring hospitalization. After puberty, women have increased asthma prevalence compared to men, and women are three times more likely to be hospitalized for an asthma-related event. These sex-specific changes in asthma prevalence and severity are known as the “asthma puberty switch”. Here, we sought to develop a murine asthma model that replicates this “switch” to enable mechanistic studies of this phenomenon. We sensitized pre- and post-pubertal BalbC/J mice of both sexes using two intraperitoneal injections of ovalbumin (50 μg in alum) on days 0 and 7. On days 14, 16, and 18, mice were challenged intranasally with antigen (50 μg of ovalbumin in saline). We quantified eosinophils in bronchoalveolar lavage fluid (BALF) and lung tissue, classified leukocytes using flow cytometry, and measured lung type 2 cytokine expression and tissue remodeling markers by qPCR. Post-puberty, antigen-challenged female mice had higher lung and BALF eosinophil counts when compared to their male littermates. Additionally, post-pubertal females had significantly higher lung tissue expression of IL-4, IL-5 and IL-13 as well as higher expression of epithelial remodeling markers tenascin, Wnt5a, and thrombospondin when compared to males. Of special significance, these sex differences were absent or reversed in pre-pubertal mice. We have shown that it is possible to replicate features of the human “asthma puberty switch” using a murine asthma model. This will enable further mechanistic studies of asthma during puberty transition." @default.
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- W2913257746 date "2019-02-01" @default.
- W2913257746 modified "2023-10-12" @default.
- W2913257746 title "A Murine Model Of Asthma That Replicates The Human Asthma Puberty Switch" @default.
- W2913257746 doi "https://doi.org/10.1016/j.jaci.2018.12.020" @default.
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