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- W2913260114 abstract "Living systems have developed complex gene networksconsisting of chaperones and quality control factors which maintainprotein homeostasis (proteostasis) by actively monitoring proteinfolding processes in an organelle-specific and dealing with proteinmisfolding in a stress-responsive manner. While we know that theseproteostasis are capable of influencing protein folding,we lack molecular details regarding how particular components ofproteostasis networks work in concert to deal with proteinmisfolding. Unfortunately, this gap in knowledge also prevents usfrom understanding the consequences of proteostasis regulation onhigher order biological processes, such as the impact chaperone andquality control factors have on protein evolution. Furthermore, weare not able to comment on how dysfunctional proteostasis networkscontribute to prominent disease states, includingneurodegeneration, cancer, and even pathogenic infections. Thus, anoverarching interest in the Shoulders lab at MIT is to fill theaforementioned knowledge gaps by studying how living metazoansystems handle protein folding problems. The lack of availablemethods for controlling the activity of proteostasis networkcomponents has significantly limited the study of proteostasis inmetazoans. In this thesis, I present work that has focused onaddressing the limitation in chemical biology tools for studyingproteostasis by developing chemical genetic methods tune the levelof proteostasis components. Similarly, the inability toconveniently explore protein folding and fitness landscapes on thelaboratory timescale has hindered the study of evolution in highereukaryotes. Thus, my later work sought to overcome this limitationby creating new evolution platforms. Though the inspiration for mywork stemmed from a desire to study proteostasis and evolution inmetazoans, the methods I developed have allowed other scientists toovercome technical limitations in their own work and progressed thestudy of many other biological processes beyondproteostasis." @default.
- W2913260114 created "2019-02-21" @default.
- W2913260114 creator A5005467263 @default.
- W2913260114 date "2018-01-01" @default.
- W2913260114 modified "2023-09-23" @default.
- W2913260114 title "Methods to study protein folding and evolution in vivo" @default.
- W2913260114 hasPublicationYear "2018" @default.
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