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- W2913263896 abstract "Introduction: Reduced left ventricular (LV) myocardial efficiency (myocardial work per O2 (MVO2)) and increased sympathetic nervous (SN) activity have been associated with the failing LV. Less is known regarding the right heart. We hypothesized that patients (pts) with RV dysfunction demonstrate increased MVO2 suggesting altered RV energetics and increased SN activity which relate to patient outcomes. Methods: 31 pts with LV systolic dysfunction and NYHA class II or III previously studied to measure LV parameters, were assessed for RV function and size using echocardiography. PET imaging was used to measure RV oxidative metabolism (11C-acetate clearance rate (kmono)) and SN function (11C-Hydroxyephedrine (HED) standard uptake values (SUVs) where decreased HED indicates increased SN activity). MVO2 was extrapolated from the linear relationship of MVO2 to kmono for the LV. Time to first cardiac event (FCE) (hospitalization for heart failure, worsening functional class, arrhythmia, heart transplantation and ..." @default.
- W2913263896 created "2019-02-21" @default.
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- W2913263896 date "2017-11-14" @default.
- W2913263896 modified "2023-09-27" @default.
- W2913263896 title "Abstract 19207: Altered Cardiac Energetics and Impaired Sympathetic Activity in Patients With Right Ventricular Failure" @default.
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