FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913264958> ?p ?o ?g. }

• W2913264958 endingPage "51" @default.
• W2913264958 startingPage "40" @default.
• W2913264958 abstract "Upregulation of special AT-rich sequence-binding protein-1 (SATB1) has been suggested to promote tumor growth and metastasis. However, the factors governing its cellular levels remain unclear. Here, we report that ubiquitin-specific peptidase 47 (USP47), a member of the deubiquitinating enzymes family, interacts with SATB1 and mediates its deubiquitination and stability. USP47 deficiency impairs transcriptional activity of SATB1 target genes and inhibits colon cancer cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer. Furthermore, we identified SMURF2 as an E3 ubiquitin ligase that promotes SATB1 degradation by upregulating its ubiquitination, and its deficiency promotes colon cancer cell proliferation and SATB1 target gene transcription. SMURF2 is negatively regulated by USP47, and USP47 depletion sensitizes colon cancer cells to 5-FU treatment-induced apoptosis. Taken together, our findings provide a ubiquitination-related mechanistic link to USP47, SMURF2, and SATB1 and suggest that USP47 might be targeted for colon cancer treatment when SATB1 is overexpressed." @default.
• W2913264958 created "2019-02-21" @default.
• W2913264958 creator A5001998362 @default.
• W2913264958 creator A5002656825 @default.
• W2913264958 creator A5004075655 @default.
• W2913264958 creator A5006487952 @default.
• W2913264958 creator A5024981671 @default.
• W2913264958 creator A5027549897 @default.
• W2913264958 creator A5032296298 @default.
• W2913264958 creator A5039100338 @default.
• W2913264958 creator A5060404389 @default.
• W2913264958 creator A5063735918 @default.
• W2913264958 creator A5065859286 @default.
• W2913264958 creator A5075549254 @default.
• W2913264958 date "2019-04-01" @default.
• W2913264958 modified "2023-10-15" @default.
• W2913264958 title "Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression" @default.
• W2913264958 cites W1814192473 @default.
• W2913264958 cites W1964845760 @default.
• W2913264958 cites W1967615841 @default.
• W2913264958 cites W1969022350 @default.
• W2913264958 cites W1985969740 @default.
• W2913264958 cites W1988810849 @default.
• W2913264958 cites W1997312107 @default.
• W2913264958 cites W2006779861 @default.
• W2913264958 cites W2007318006 @default.
• W2913264958 cites W2012081711 @default.
• W2913264958 cites W2017756762 @default.
• W2913264958 cites W2020053069 @default.
• W2913264958 cites W2021170422 @default.
• W2913264958 cites W2023016929 @default.
• W2913264958 cites W2032206017 @default.
• W2913264958 cites W2033421854 @default.
• W2913264958 cites W2051893623 @default.
• W2913264958 cites W2059779437 @default.
• W2913264958 cites W2067361089 @default.
• W2913264958 cites W2072442030 @default.
• W2913264958 cites W2081160997 @default.
• W2913264958 cites W2082613563 @default.
• W2913264958 cites W2088724822 @default.
• W2913264958 cites W2094706459 @default.
• W2913264958 cites W2096136519 @default.
• W2913264958 cites W2103017472 @default.
• W2913264958 cites W2118225942 @default.
• W2913264958 cites W2122026938 @default.
• W2913264958 cites W2126840542 @default.
• W2913264958 cites W2136164908 @default.
• W2913264958 cites W2142237411 @default.
• W2913264958 cites W2156475356 @default.
• W2913264958 cites W2157718895 @default.
• W2913264958 cites W2163880258 @default.
• W2913264958 cites W2215718122 @default.
• W2913264958 cites W2259350898 @default.
• W2913264958 cites W2572272477 @default.
• W2913264958 cites W2600749459 @default.
• W2913264958 cites W2626359644 @default.
• W2913264958 cites W2765737507 @default.
• W2913264958 cites W2770906567 @default.
• W2913264958 doi "https://doi.org/10.1016/j.canlet.2019.01.039" @default.
• W2913264958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742943" @default.
• W2913264958 hasPublicationYear "2019" @default.
• W2913264958 type Work @default.
• W2913264958 sameAs 2913264958 @default.
• W2913264958 citedByCount "55" @default.
• W2913264958 countsByYear W29132649582019 @default.
• W2913264958 countsByYear W29132649582020 @default.
• W2913264958 countsByYear W29132649582021 @default.
• W2913264958 countsByYear W29132649582022 @default.
• W2913264958 countsByYear W29132649582023 @default.
• W2913264958 crossrefType "journal-article" @default.
• W2913264958 hasAuthorship W2913264958A5001998362 @default.
• W2913264958 hasAuthorship W2913264958A5002656825 @default.
• W2913264958 hasAuthorship W2913264958A5004075655 @default.
• W2913264958 hasAuthorship W2913264958A5006487952 @default.
• W2913264958 hasAuthorship W2913264958A5024981671 @default.
• W2913264958 hasAuthorship W2913264958A5027549897 @default.
• W2913264958 hasAuthorship W2913264958A5032296298 @default.
• W2913264958 hasAuthorship W2913264958A5039100338 @default.
• W2913264958 hasAuthorship W2913264958A5060404389 @default.
• W2913264958 hasAuthorship W2913264958A5063735918 @default.
• W2913264958 hasAuthorship W2913264958A5065859286 @default.
• W2913264958 hasAuthorship W2913264958A5075549254 @default.
• W2913264958 hasConcept C102658986 @default.
• W2913264958 hasConcept C104317684 @default.
• W2913264958 hasConcept C121608353 @default.
• W2913264958 hasConcept C127561419 @default.
• W2913264958 hasConcept C134459356 @default.
• W2913264958 hasConcept C25602115 @default.
• W2913264958 hasConcept C502942594 @default.
• W2913264958 hasConcept C526805850 @default.
• W2913264958 hasConcept C54355233 @default.
• W2913264958 hasConcept C55493867 @default.
• W2913264958 hasConcept C555283112 @default.
• W2913264958 hasConcept C62112901 @default.
• W2913264958 hasConcept C86803240 @default.
• W2913264958 hasConcept C95444343 @default.
• W2913264958 hasConceptScore W2913264958C102658986 @default.
• W2913264958 hasConceptScore W2913264958C104317684 @default.

• next