Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913267557> ?p ?o ?g. }
- W2913267557 endingPage "185" @default.
- W2913267557 startingPage "177" @default.
- W2913267557 abstract "Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. In this manuscript, 171 nm switchable lipid nanoparticles (LNP) co-delivered melphalan and miR-181a with encapsulation efficiencies of 93%. Encapsulation of melphalan in LNP significantly improved its therapeutic efficiency. Gene analysis shows that miR-181a decreases the expression of anti-proliferative gene MAPK1 and anti-apoptotic gene Bcl-2, but significantly increased the expression of pro-apoptotic gene BAX. Our results suggest that the two agents have a complementary effect in reducing the viability of cultured Rb cells (primary and cell line) and decreasing Rb cell counts in an in-vivo xenograft Rb model in rats. Our results suggest that the proposed co-delivery technique significantly increases the therapeutic impact, allows for lower administration of melphalan, and consequently, could minimize the cytotoxic side-effects of this drug." @default.
- W2913267557 created "2019-02-21" @default.
- W2913267557 creator A5002975417 @default.
- W2913267557 creator A5008347911 @default.
- W2913267557 creator A5011479404 @default.
- W2913267557 creator A5013451032 @default.
- W2913267557 creator A5035931018 @default.
- W2913267557 creator A5044968264 @default.
- W2913267557 creator A5067115954 @default.
- W2913267557 date "2019-03-01" @default.
- W2913267557 modified "2023-10-15" @default.
- W2913267557 title "Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma" @default.
- W2913267557 cites W1830713541 @default.
- W2913267557 cites W1859037964 @default.
- W2913267557 cites W1977342490 @default.
- W2913267557 cites W1980760089 @default.
- W2913267557 cites W1981299851 @default.
- W2913267557 cites W1984536924 @default.
- W2913267557 cites W1987077074 @default.
- W2913267557 cites W2007982736 @default.
- W2913267557 cites W2010731545 @default.
- W2913267557 cites W2018516156 @default.
- W2913267557 cites W2024504116 @default.
- W2913267557 cites W2038653853 @default.
- W2913267557 cites W2039551908 @default.
- W2913267557 cites W2040744038 @default.
- W2913267557 cites W2045367662 @default.
- W2913267557 cites W2047468566 @default.
- W2913267557 cites W2061810043 @default.
- W2913267557 cites W2066113694 @default.
- W2913267557 cites W2080327351 @default.
- W2913267557 cites W2080627917 @default.
- W2913267557 cites W2083381199 @default.
- W2913267557 cites W2084295352 @default.
- W2913267557 cites W2107232075 @default.
- W2913267557 cites W2134629862 @default.
- W2913267557 cites W2139243971 @default.
- W2913267557 cites W2144753743 @default.
- W2913267557 cites W2148199584 @default.
- W2913267557 cites W2233414233 @default.
- W2913267557 cites W2279619364 @default.
- W2913267557 cites W2400680206 @default.
- W2913267557 cites W2417893665 @default.
- W2913267557 cites W2472461574 @default.
- W2913267557 cites W2489337449 @default.
- W2913267557 cites W2520003103 @default.
- W2913267557 cites W2536038703 @default.
- W2913267557 cites W2549111532 @default.
- W2913267557 cites W2550293882 @default.
- W2913267557 cites W2587005936 @default.
- W2913267557 cites W2591113906 @default.
- W2913267557 cites W2603336835 @default.
- W2913267557 cites W2618836931 @default.
- W2913267557 cites W2730933490 @default.
- W2913267557 cites W2772878912 @default.
- W2913267557 cites W2793858261 @default.
- W2913267557 cites W2798032168 @default.
- W2913267557 cites W2800488651 @default.
- W2913267557 doi "https://doi.org/10.1016/j.jconrel.2019.02.014" @default.
- W2913267557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776396" @default.
- W2913267557 hasPublicationYear "2019" @default.
- W2913267557 type Work @default.
- W2913267557 sameAs 2913267557 @default.
- W2913267557 citedByCount "56" @default.
- W2913267557 countsByYear W29132675572019 @default.
- W2913267557 countsByYear W29132675572020 @default.
- W2913267557 countsByYear W29132675572021 @default.
- W2913267557 countsByYear W29132675572022 @default.
- W2913267557 countsByYear W29132675572023 @default.
- W2913267557 crossrefType "journal-article" @default.
- W2913267557 hasAuthorship W2913267557A5002975417 @default.
- W2913267557 hasAuthorship W2913267557A5008347911 @default.
- W2913267557 hasAuthorship W2913267557A5011479404 @default.
- W2913267557 hasAuthorship W2913267557A5013451032 @default.
- W2913267557 hasAuthorship W2913267557A5035931018 @default.
- W2913267557 hasAuthorship W2913267557A5044968264 @default.
- W2913267557 hasAuthorship W2913267557A5067115954 @default.
- W2913267557 hasBestOaLocation W29132675571 @default.
- W2913267557 hasConcept C104317684 @default.
- W2913267557 hasConcept C109316439 @default.
- W2913267557 hasConcept C135983454 @default.
- W2913267557 hasConcept C145059251 @default.
- W2913267557 hasConcept C150903083 @default.
- W2913267557 hasConcept C154317977 @default.
- W2913267557 hasConcept C185592680 @default.
- W2913267557 hasConcept C190283241 @default.
- W2913267557 hasConcept C202751555 @default.
- W2913267557 hasConcept C203014093 @default.
- W2913267557 hasConcept C207001950 @default.
- W2913267557 hasConcept C2776364478 @default.
- W2913267557 hasConcept C2776577112 @default.
- W2913267557 hasConcept C2778684742 @default.
- W2913267557 hasConcept C2780035454 @default.
- W2913267557 hasConcept C502942594 @default.
- W2913267557 hasConcept C53227056 @default.
- W2913267557 hasConcept C54009773 @default.
- W2913267557 hasConcept C55493867 @default.
- W2913267557 hasConcept C86803240 @default.