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- W2913271237 abstract "Aim: To estimate efficacy of checkpoint inhibitors and rank treatment effects in non-small-cell lung cancer. Materials & methods: Prospective randomized trials were included. p-score was used to rank treatment effects. Results: A total of nine trials were identified, involving 5504 patients and three checkpoint inhibitors. Pembrolizumab plus chemotherapy had the highest p-score of 0.95 among all the treatments, and was superior to pembrolizumab alone (hazard ratio: 0.87; 95% CI: 0.79–0.95). Combination therapy had more grade 3–5 adverse events; but toxicity-related discontinuation and treatment-related death did not increase. Conclusion: Pembrolizumab plus chemotherapy was likely to be the most effective treatment for patients with wild-type advanced NSCLC." @default.
- W2913271237 created "2019-02-21" @default.
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- W2913271237 date "2019-03-01" @default.
- W2913271237 modified "2023-10-04" @default.
- W2913271237 title "First-line checkpoint inhibitors for wild-type advanced non-small-cell cancer: a pair-wise and network meta-analysis" @default.
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- W2913271237 doi "https://doi.org/10.2217/imt-2018-0107" @default.
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