Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913274732> ?p ?o ?g. }
- W2913274732 endingPage "71" @default.
- W2913274732 startingPage "61" @default.
- W2913274732 abstract "The canonical effect of Pregnane X Receptor (PXR, NR1I2) agonism includes enhanced hepatic uptake and a concomitant increase in the first-pass metabolism and efflux of drugs in mammalian liver and intestine. In patients undergoing combination therapy, PXR-mediated gene regulation represents the molecular basis of numerous food-drug, herb-drug, and drug-drug interactions. Moreover, PXR activation promotes chemotherapeutic resistance in certain malignancies. Additional research efforts suggest that sustained PXR activation exacerbates the development of fatty liver disease. Additional metabolic effects of PXR activation in liver are the inhibition of fatty acid oxidation and gluconeogenesis. The identification of non-toxic and selective PXR antagonists is therefore of current research interest. Inhibition of PXR should decrease adverse effects, improve therapeutic effectiveness, and advance clinical outcomes in patients with cancer, fatty liver, and diabetes. This review identifies small molecule PXR antagonists described to date, discusses possible molecular mechanisms of inhibition, and seeks to describe the likely biomedical consequences of the inhibition of this nuclear receptor superfamily member." @default.
- W2913274732 created "2019-02-21" @default.
- W2913274732 creator A5006135810 @default.
- W2913274732 date "2019-04-01" @default.
- W2913274732 modified "2023-09-30" @default.
- W2913274732 title "Clinical applications of small molecule inhibitors of Pregnane X receptor" @default.
- W2913274732 cites W1496168405 @default.
- W2913274732 cites W1545401674 @default.
- W2913274732 cites W1908388533 @default.
- W2913274732 cites W1964710172 @default.
- W2913274732 cites W1966531138 @default.
- W2913274732 cites W1967077010 @default.
- W2913274732 cites W1968535758 @default.
- W2913274732 cites W1970187819 @default.
- W2913274732 cites W1975455503 @default.
- W2913274732 cites W1978213778 @default.
- W2913274732 cites W1985914288 @default.
- W2913274732 cites W1991095764 @default.
- W2913274732 cites W1994307044 @default.
- W2913274732 cites W1995193962 @default.
- W2913274732 cites W1996011325 @default.
- W2913274732 cites W2000873867 @default.
- W2913274732 cites W2003599782 @default.
- W2913274732 cites W2005026027 @default.
- W2913274732 cites W2008362176 @default.
- W2913274732 cites W2008785161 @default.
- W2913274732 cites W2009476878 @default.
- W2913274732 cites W2009838390 @default.
- W2913274732 cites W2016095632 @default.
- W2913274732 cites W2018185888 @default.
- W2913274732 cites W2021444563 @default.
- W2913274732 cites W2023901364 @default.
- W2913274732 cites W2026383483 @default.
- W2913274732 cites W2026885757 @default.
- W2913274732 cites W2028890879 @default.
- W2913274732 cites W2032693719 @default.
- W2913274732 cites W2033814857 @default.
- W2913274732 cites W2034217761 @default.
- W2913274732 cites W2034503330 @default.
- W2913274732 cites W2035000881 @default.
- W2913274732 cites W2036657821 @default.
- W2913274732 cites W2037657593 @default.
- W2913274732 cites W2042763169 @default.
- W2913274732 cites W2043249607 @default.
- W2913274732 cites W2043826533 @default.
- W2913274732 cites W2044911368 @default.
- W2913274732 cites W2046157279 @default.
- W2913274732 cites W2051092460 @default.
- W2913274732 cites W2051602682 @default.
- W2913274732 cites W2051746949 @default.
- W2913274732 cites W2057626046 @default.
- W2913274732 cites W2061222476 @default.
- W2913274732 cites W2063559426 @default.
- W2913274732 cites W2064185967 @default.
- W2913274732 cites W2066867171 @default.
- W2913274732 cites W2067961925 @default.
- W2913274732 cites W2068110028 @default.
- W2913274732 cites W2072822958 @default.
- W2913274732 cites W2073714219 @default.
- W2913274732 cites W2075903510 @default.
- W2913274732 cites W2076565275 @default.
- W2913274732 cites W2076985436 @default.
- W2913274732 cites W2078056360 @default.
- W2913274732 cites W2079080809 @default.
- W2913274732 cites W2084462922 @default.
- W2913274732 cites W2085287557 @default.
- W2913274732 cites W2089708610 @default.
- W2913274732 cites W2093055796 @default.
- W2913274732 cites W2095886291 @default.
- W2913274732 cites W2098568145 @default.
- W2913274732 cites W2100100424 @default.
- W2913274732 cites W2103863911 @default.
- W2913274732 cites W2108055984 @default.
- W2913274732 cites W2109385821 @default.
- W2913274732 cites W2114733497 @default.
- W2913274732 cites W2115397306 @default.
- W2913274732 cites W2121030616 @default.
- W2913274732 cites W2122267374 @default.
- W2913274732 cites W2125457175 @default.
- W2913274732 cites W2128999057 @default.
- W2913274732 cites W2129977645 @default.
- W2913274732 cites W2132083523 @default.
- W2913274732 cites W2142105589 @default.
- W2913274732 cites W2142110193 @default.
- W2913274732 cites W2143492487 @default.
- W2913274732 cites W2143953127 @default.
- W2913274732 cites W2145800770 @default.
- W2913274732 cites W2149038504 @default.
- W2913274732 cites W2156715171 @default.
- W2913274732 cites W2156790027 @default.
- W2913274732 cites W2157270895 @default.
- W2913274732 cites W2160450046 @default.
- W2913274732 cites W2161816485 @default.
- W2913274732 cites W2168161686 @default.
- W2913274732 cites W2171106895 @default.
- W2913274732 cites W2172132778 @default.
- W2913274732 cites W2324212377 @default.
- W2913274732 cites W2327808590 @default.