Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913304567> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2913304567 abstract "AbstractAlthough NVP-BEZ235 and XAV-939 have been shown a promising result in the treatment of colorectal cancer (CRC), our data is little with regard to the effect of environmental cytokine on this drugs. In order to explore the reaction of CRC to this novel therapy, the current study proposes to investigate the inhibitory effect of NVP-BEZ235 and/or XAV-939 in CRC cells in combination with TGF-beta as a tumor environmental cytokine to analyze their effect on cancer cell proliferation, cell death and expression of cancer promoting genes. The cells were treated with single or combination of NVP-BEZ235, XAV-939 and TGF-beta. Cell viability was evaluated by MTT assay. Flow cytometry method was used to determine cellular death. Real-time PCR was utilized to identify the effect of treatments on expression of snail, slug, C-myc and notchl genes. The results revealed that NVP-BEZ235 inhibited CRC cells proliferation and induced senescence cells more than XAV-939. Although, XAV-939 increased cellular death and inhibited senescence induction of CRC cells better than NVP-BEZ235. TGF-beta pretreatment sensitizes CRC cells to the cytotoxic effect of NVP-BEZ235 and XAV-939. Real-time PCR analysis showed that resistance cells to NVP-BEZ235 increased expression of slug. Expression of notch enhanced remarkably when cells treated with both NVP-BEZ235 and XAV-939. The results of the present study demonstrated that presence of anti-inflammatory cytokine like TGF-beta augments the inhibitory effect of XAV-939 or especially NVP-BEZ235." @default.
- W2913304567 created "2019-02-21" @default.
- W2913304567 creator A5040236545 @default.
- W2913304567 creator A5051650401 @default.
- W2913304567 creator A5080581578 @default.
- W2913304567 date "2018-01-01" @default.
- W2913304567 modified "2023-09-23" @default.
- W2913304567 title "TGF-beta INCREASES CYTOTOXIC EFFECT AND SENESCENCE INDUCED BY PI3K/ AKT/ MTOR INHIBITOR IN HUMAN COLORECTAL CANCER CELLS" @default.
- W2913304567 hasPublicationYear "2018" @default.
- W2913304567 type Work @default.
- W2913304567 sameAs 2913304567 @default.
- W2913304567 citedByCount "0" @default.
- W2913304567 crossrefType "journal-article" @default.
- W2913304567 hasAuthorship W2913304567A5040236545 @default.
- W2913304567 hasAuthorship W2913304567A5051650401 @default.
- W2913304567 hasAuthorship W2913304567A5080581578 @default.
- W2913304567 hasConcept C121608353 @default.
- W2913304567 hasConcept C126322002 @default.
- W2913304567 hasConcept C154317977 @default.
- W2913304567 hasConcept C190283241 @default.
- W2913304567 hasConcept C202751555 @default.
- W2913304567 hasConcept C203014093 @default.
- W2913304567 hasConcept C2778690821 @default.
- W2913304567 hasConcept C502942594 @default.
- W2913304567 hasConcept C526805850 @default.
- W2913304567 hasConcept C553184892 @default.
- W2913304567 hasConcept C55493867 @default.
- W2913304567 hasConcept C71924100 @default.
- W2913304567 hasConcept C86554907 @default.
- W2913304567 hasConcept C86803240 @default.
- W2913304567 hasConcept C96232424 @default.
- W2913304567 hasConceptScore W2913304567C121608353 @default.
- W2913304567 hasConceptScore W2913304567C126322002 @default.
- W2913304567 hasConceptScore W2913304567C154317977 @default.
- W2913304567 hasConceptScore W2913304567C190283241 @default.
- W2913304567 hasConceptScore W2913304567C202751555 @default.
- W2913304567 hasConceptScore W2913304567C203014093 @default.
- W2913304567 hasConceptScore W2913304567C2778690821 @default.
- W2913304567 hasConceptScore W2913304567C502942594 @default.
- W2913304567 hasConceptScore W2913304567C526805850 @default.
- W2913304567 hasConceptScore W2913304567C553184892 @default.
- W2913304567 hasConceptScore W2913304567C55493867 @default.
- W2913304567 hasConceptScore W2913304567C71924100 @default.
- W2913304567 hasConceptScore W2913304567C86554907 @default.
- W2913304567 hasConceptScore W2913304567C86803240 @default.
- W2913304567 hasConceptScore W2913304567C96232424 @default.
- W2913304567 hasLocation W29133045671 @default.
- W2913304567 hasOpenAccess W2913304567 @default.
- W2913304567 hasPrimaryLocation W29133045671 @default.
- W2913304567 hasRelatedWork W1977659356 @default.
- W2913304567 hasRelatedWork W2008431249 @default.
- W2913304567 hasRelatedWork W2013299905 @default.
- W2913304567 hasRelatedWork W2041903098 @default.
- W2913304567 hasRelatedWork W2346515569 @default.
- W2913304567 hasRelatedWork W2476698294 @default.
- W2913304567 hasRelatedWork W2478493914 @default.
- W2913304567 hasRelatedWork W2756187670 @default.
- W2913304567 hasRelatedWork W2899080264 @default.
- W2913304567 hasRelatedWork W2944165342 @default.
- W2913304567 hasRelatedWork W2957092169 @default.
- W2913304567 hasRelatedWork W2980386806 @default.
- W2913304567 hasRelatedWork W2990712492 @default.
- W2913304567 hasRelatedWork W3008402902 @default.
- W2913304567 hasRelatedWork W3028624729 @default.
- W2913304567 hasRelatedWork W3034029304 @default.
- W2913304567 hasRelatedWork W3119208567 @default.
- W2913304567 hasRelatedWork W3156994599 @default.
- W2913304567 hasRelatedWork W3197014831 @default.
- W2913304567 hasRelatedWork W3201255562 @default.
- W2913304567 isParatext "false" @default.
- W2913304567 isRetracted "false" @default.
- W2913304567 magId "2913304567" @default.
- W2913304567 workType "article" @default.