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- W2913304797 abstract "Abstract Although venous thromboembolism (VTE) is a well-known cause of death in patients with cancer, both its treatment and prevention remain a challenge in daily practice. Direct oral anticoagulants have emerged as safe and efficacious alternatives to vitamin K antagonists in the general population, and recent clinical trials also support their use in select patients with cancer-associated VTE. Despite this, low-molecular-weight heparins (LMWHs), a comparatively ancient class of antithrombotic drugs, remain the anticoagulants of choice in many indications relevant to modern haematology and oncology. In addition to the treatment of established VTE, these indications include VTE prophylaxis in surgical or acutely ill, hospitalized medical cancer patients as well as the prevention of VTE in high-risk patients undergoing ambulatory chemotherapy. In a constantly changing landscape of approved anticancer agents, this review article summarizes pivotal clinical trial data and guideline recommendations regarding the use of LMWH in haematological and oncological patients, who constitute a highly vulnerable patient population due to their increased risk for both bleeding and VTE recurrence." @default.
- W2913304797 created "2019-02-21" @default.
- W2913304797 creator A5003482383 @default.
- W2913304797 creator A5029294865 @default.
- W2913304797 date "2019-01-31" @default.
- W2913304797 modified "2023-09-25" @default.
- W2913304797 title "Low-Molecular-Weight Heparin in Cancer Patients: Overview and Indications" @default.
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- W2913304797 doi "https://doi.org/10.1055/s-0039-1677796" @default.
- W2913304797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30703821" @default.
- W2913304797 hasPublicationYear "2019" @default.
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