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• W2913355596 abstract "Objective: In Germany, thousands of patients with MS (pwMS) are treated by neurologists in private praxis. Although BICAMS (Brief International Cognitive Assessment for MS) was introduced in 2012 as optimized tool for small centers with only few staff members, gained experience over the past years illustrates that a 15 to 20-minutes screening test application is not feasible in non-university clinical settings. We therefore aimed at examining whether BICAMS might be shortened to reduce administration time without losing sensitivity. Background: BICAMS has been proposed as international screening tool to homogenize cognitive assessment across countries. Design/Methods: 1221 MS patients screened in a multi-centre design in Germany entered final analysis (age: M=43, SD=11.23; female: 73.4%). SDMT z-scores lower than −1.65 and VLMT (equivalent of CVLT-II in Germany) as well as BVMT-R percentage scores lower than 16 were set as diagnostic cut-off scores for cognitive impairment. A patient’s cognition was classified as impaired when at least one of the three test scores of the total BICAMS battery or at least one of the two tests of the combinations were below the clinical cut-off scores. Test-conformity with BICAMS was defined by overall hit rates and correct rejections, respectively. Results: 40.6% of screened MS patients were detected as cognitively impaired when the total BICAMS battery was applied. The combination of SDMT and BVMT-R (93.6%, p=.001) reached a significantly higher conformity with the total battery than the combination of SDMT and VLMT (89.5%). Each combination of two tests was more conform with the total BICAMS battery than the application of single tests. Conclusions: We conclude that the combined administration of SDMT and BVMT-R enables to detect cognitively impaired MS patients in a more time economic way (10–12 minutes) but as reliable as the total battery. This combination is therefore recommended for patient-centered care in small centers. Study Supported by: Research Grant from Novartis Disclosure: Dr. Penner has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Adamas Pharma, Bayer Pharma, Biogen GmbH, Desitin, Genzyme, Merck Serono, Novartis Pharma GmbH, Roche and Teva. Dr. Penner has received research support from Teva. Dr. Filser has nothing to disclose. Dr. Renner has nothing to disclose. Dr. Ullrich has nothing to disclose. Dr. Lassek has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen, Genzyme, Novartis, Teva. Dr. Lassek has received research support from Biogen, Genzyme, Novartis, Teva. Dr. Baetge has nothing to disclose." @default.
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• W2913355596 date "2018-04-10" @default.
• W2913355596 modified "2023-09-23" @default.
• W2913355596 title "Screening of cognitive impairment in patients with multiple sclerosis (MS): the BICAMS short version for patient-centered care in small neurological institutions (P2.420)" @default.
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