Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913357915> ?p ?o ?g. }
- W2913357915 endingPage "959" @default.
- W2913357915 startingPage "949" @default.
- W2913357915 abstract "Treatment of cancer has evolved in the last decade with the introduction of new therapies. Despite these successes, the lingering cardiotoxic side-effects from chemotherapy remain a major cause of morbidity and mortality in cancer survivors. These effects can develop acutely during treatment, or even years later. Although many risk factors can be identified prior to beginning therapy, unexpected toxicity still occurs, often with lasting consequences. Specifically, cardiotoxicity results in cardiac cell death, eventually leading to cardiomyopathy and heart failure. Certain risk factors may predispose an individual to experiencing adverse cardiovascular effects, and when unexpected cardiotoxicity occurs, it is generally managed with supportive care. Animal models of chemotherapy-induced cardiotoxicity have provided some mechanistic insights, but the precise mechanisms by which these drugs affect the heart remains unknown. Moreover, the genetic rationale as to why some patients are more susceptible to developing cardiotoxicity has yet to be determined. Many genome-wide association studies have identified genomic variants that could be associated with chemotherapy-induced cardiotoxicity, but the lack of validation has made these studies more speculative rather than definitive. With the advent of human induced pluripotent stem cell (iPSC) technology, researchers not only have the opportunity to model human diseases, but also to screen drugs for their efficacy and toxicity using human cell models. Furthermore, it allows us to conduct validation studies to confirm the role of genomic variants in human diseases. In this review, we discuss the role of iPSCs in modelling chemotherapy-induced cardiotoxicity." @default.
- W2913357915 created "2019-02-21" @default.
- W2913357915 creator A5031964598 @default.
- W2913357915 creator A5047561254 @default.
- W2913357915 creator A5075475491 @default.
- W2913357915 date "2019-02-15" @default.
- W2913357915 modified "2023-10-03" @default.
- W2913357915 title "Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell" @default.
- W2913357915 cites W1492360552 @default.
- W2913357915 cites W1542075887 @default.
- W2913357915 cites W1602031286 @default.
- W2913357915 cites W1840448288 @default.
- W2913357915 cites W1871377835 @default.
- W2913357915 cites W1880435494 @default.
- W2913357915 cites W1898753515 @default.
- W2913357915 cites W1968207082 @default.
- W2913357915 cites W1977622321 @default.
- W2913357915 cites W1982411138 @default.
- W2913357915 cites W1985439976 @default.
- W2913357915 cites W1988506250 @default.
- W2913357915 cites W1990602451 @default.
- W2913357915 cites W1991801094 @default.
- W2913357915 cites W1998990808 @default.
- W2913357915 cites W200355954 @default.
- W2913357915 cites W2009946366 @default.
- W2913357915 cites W2012405585 @default.
- W2913357915 cites W2015345028 @default.
- W2913357915 cites W2019271482 @default.
- W2913357915 cites W2020312840 @default.
- W2913357915 cites W2020849074 @default.
- W2913357915 cites W2024013564 @default.
- W2913357915 cites W2034322504 @default.
- W2913357915 cites W2038985537 @default.
- W2913357915 cites W2046973998 @default.
- W2913357915 cites W2050216284 @default.
- W2913357915 cites W2055143260 @default.
- W2913357915 cites W2066390373 @default.
- W2913357915 cites W2068412287 @default.
- W2913357915 cites W2070202276 @default.
- W2913357915 cites W2075574520 @default.
- W2913357915 cites W2075926302 @default.
- W2913357915 cites W2080329939 @default.
- W2913357915 cites W2093032646 @default.
- W2913357915 cites W2096322385 @default.
- W2913357915 cites W2099359513 @default.
- W2913357915 cites W2100173894 @default.
- W2913357915 cites W2104790299 @default.
- W2913357915 cites W2108903695 @default.
- W2913357915 cites W2112357840 @default.
- W2913357915 cites W2116949558 @default.
- W2913357915 cites W2119010176 @default.
- W2913357915 cites W2122249540 @default.
- W2913357915 cites W2128772718 @default.
- W2913357915 cites W2132925893 @default.
- W2913357915 cites W2135015334 @default.
- W2913357915 cites W2138977668 @default.
- W2913357915 cites W2139223358 @default.
- W2913357915 cites W2140182328 @default.
- W2913357915 cites W2141393790 @default.
- W2913357915 cites W2141469083 @default.
- W2913357915 cites W2142046859 @default.
- W2913357915 cites W2147646179 @default.
- W2913357915 cites W2150475243 @default.
- W2913357915 cites W2151490188 @default.
- W2913357915 cites W2152190103 @default.
- W2913357915 cites W2153362990 @default.
- W2913357915 cites W2157732921 @default.
- W2913357915 cites W2163495162 @default.
- W2913357915 cites W2164802689 @default.
- W2913357915 cites W2166714629 @default.
- W2913357915 cites W2167781187 @default.
- W2913357915 cites W2169631942 @default.
- W2913357915 cites W2193716145 @default.
- W2913357915 cites W2227148039 @default.
- W2913357915 cites W2250963847 @default.
- W2913357915 cites W2295465207 @default.
- W2913357915 cites W2300709768 @default.
- W2913357915 cites W2318605753 @default.
- W2913357915 cites W2319329168 @default.
- W2913357915 cites W2322570510 @default.
- W2913357915 cites W2330864738 @default.
- W2913357915 cites W2338021849 @default.
- W2913357915 cites W2344631847 @default.
- W2913357915 cites W2346922699 @default.
- W2913357915 cites W2409893933 @default.
- W2913357915 cites W2414035669 @default.
- W2913357915 cites W2465010046 @default.
- W2913357915 cites W2467918428 @default.
- W2913357915 cites W2511645685 @default.
- W2913357915 cites W2512832185 @default.
- W2913357915 cites W2521812185 @default.
- W2913357915 cites W2530366440 @default.
- W2913357915 cites W2544855682 @default.
- W2913357915 cites W2547133566 @default.
- W2913357915 cites W2555338771 @default.
- W2913357915 cites W2559028527 @default.
- W2913357915 cites W2560367415 @default.
- W2913357915 cites W2566843361 @default.