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• W2913363945 startingPage "155" @default.
• W2913363945 abstract "Core-virus like particles (VLPs) assembly is a kinetically complex cascade of interactions between viral proteins, nanoparticle’s surface and an ionic environment. Despite many in silico simulations regarding this process, there is still a lack of experimental data. The main goal of this study was to investigate the capsid protein of hepatitis B virus (HBc) assembly into virus-like particles with superparamagnetic iron oxide nanoparticles (SPIONs) as a magnetic core in relation to their characteristics. The native form of HBc was obtained via agroinfection of Nicotiana benthamiana with pEAQ-HBc plasmid. SPIONs of diameter of 15 nm were synthesized and functionalized with two ligands, providing variety in ζ-potential and hydrodynamic diameter. The antigenic potential of the assembled core-VLPs was assessed with enzyme-linked immunosorbent assay (ELISA). Morphology of SPIONs and core-VLPs was evaluated via transmission electron microscopy (TEM). The most successful core-VLPs assembly was obtained for SPIONs functionalized with dihexadecyl phosphate (DHP) at SPIONs/HBc ratio of 0.2/0.05 mg/mL. ELISA results indicate significant decrease of antigenicity concomitant with core-VLPs assembly. In summary, this study provides an experimental assessment of the crucial parameters guiding SPION-HBc VLPs assembly and evaluates the antigenicity of the obtained structures." @default.
• W2913363945 created "2019-02-21" @default.
• W2913363945 creator A5052305649 @default.
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• W2913363945 date "2019-01-26" @default.
• W2913363945 modified "2023-10-18" @default.
• W2913363945 title "Assembly and Characterization of HBc Derived Virus-like Particles with Magnetic Core" @default.
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• W2913363945 doi "https://doi.org/10.3390/nano9020155" @default.
• W2913363945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6409934" @default.
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• W2913363945 hasPublicationYear "2019" @default.
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