FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913378097> ?p ?o ?g. }

• W2913378097 endingPage "650" @default.
• W2913378097 startingPage "637" @default.
• W2913378097 abstract "Abstract In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establishes long-term size homeostasis. Our former investigations have shown that hundreds of genes markedly altered cell size under homeostatic growth conditions in the opportunistic yeast Candida albicans, but surprisingly only few of these overlapped with size control genes in the budding yeast Saccharomyces cerevisiae. Here, we investigated one of the divergent potent size regulators in C. albicans, the Myb-like HTH transcription factor Dot6. Our data demonstrated that Dot6 is a negative regulator of Start, and also acts as a transcriptional activator of ribosome biogenesis (Ribi) genes. Genetic epistasis uncovered that Dot6 interacted with the master transcriptional regulator of the G1 machinery, SBF complex, but not with the Ribi and cell size regulators Sch9, Sfp1, and p38/Hog1. Dot6 was required for carbon-source modulation of cell size, and it is regulated at the level of nuclear localization by the TOR pathway. Our findings support a model where Dot6 acts as a hub that integrates growth cues directly via the TOR pathway to control the commitment to mitotic division at G1." @default.
• W2913378097 created "2019-02-21" @default.
• W2913378097 creator A5004084748 @default.
• W2913378097 creator A5026106199 @default.
• W2913378097 creator A5037685521 @default.
• W2913378097 creator A5048742327 @default.
• W2913378097 date "2018-12-27" @default.
• W2913378097 modified "2023-10-12" @default.
• W2913378097 title "Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in <i>Candida albicans</i>" @default.
• W2913378097 cites W169216998 @default.
• W2913378097 cites W1908298847 @default.
• W2913378097 cites W1975471112 @default.
• W2913378097 cites W1978257350 @default.
• W2913378097 cites W1987342892 @default.
• W2913378097 cites W1996460711 @default.
• W2913378097 cites W2000860171 @default.
• W2913378097 cites W2006754735 @default.
• W2913378097 cites W2015038174 @default.
• W2913378097 cites W2017017064 @default.
• W2913378097 cites W2026265704 @default.
• W2913378097 cites W2026969336 @default.
• W2913378097 cites W2033304975 @default.
• W2913378097 cites W2035273639 @default.
• W2913378097 cites W2037667706 @default.
• W2913378097 cites W2041611856 @default.
• W2913378097 cites W2076583650 @default.
• W2913378097 cites W2078477504 @default.
• W2913378097 cites W2084737875 @default.
• W2913378097 cites W2088127501 @default.
• W2913378097 cites W2089940194 @default.
• W2913378097 cites W2097948046 @default.
• W2913378097 cites W2098337864 @default.
• W2913378097 cites W2101199478 @default.
• W2913378097 cites W2107835138 @default.
• W2913378097 cites W2110037042 @default.
• W2913378097 cites W2117490246 @default.
• W2913378097 cites W2119456700 @default.
• W2913378097 cites W2123416375 @default.
• W2913378097 cites W2125176616 @default.
• W2913378097 cites W2128003379 @default.
• W2913378097 cites W2130410032 @default.
• W2913378097 cites W2135014189 @default.
• W2913378097 cites W2135741099 @default.
• W2913378097 cites W2138156268 @default.
• W2913378097 cites W2141450355 @default.
• W2913378097 cites W2151682452 @default.
• W2913378097 cites W2158611476 @default.
• W2913378097 cites W2161594264 @default.
• W2913378097 cites W2166117618 @default.
• W2913378097 cites W2172213445 @default.
• W2913378097 cites W2177398160 @default.
• W2913378097 cites W2219121760 @default.
• W2913378097 cites W2339307955 @default.
• W2913378097 cites W2580026892 @default.
• W2913378097 doi "https://doi.org/10.1534/genetics.118.301872" @default.
• W2913378097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6366905" @default.
• W2913378097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30593490" @default.
• W2913378097 hasPublicationYear "2018" @default.
• W2913378097 type Work @default.
• W2913378097 sameAs 2913378097 @default.
• W2913378097 citedByCount "11" @default.
• W2913378097 countsByYear W29133780972020 @default.
• W2913378097 countsByYear W29133780972021 @default.
• W2913378097 countsByYear W29133780972022 @default.
• W2913378097 countsByYear W29133780972023 @default.
• W2913378097 crossrefType "journal-article" @default.
• W2913378097 hasAuthorship W2913378097A5004084748 @default.
• W2913378097 hasAuthorship W2913378097A5026106199 @default.
• W2913378097 hasAuthorship W2913378097A5037685521 @default.
• W2913378097 hasAuthorship W2913378097A5048742327 @default.
• W2913378097 hasBestOaLocation W29133780971 @default.
• W2913378097 hasConcept C104317684 @default.
• W2913378097 hasConcept C1491633281 @default.
• W2913378097 hasConcept C2777576037 @default.
• W2913378097 hasConcept C2779419633 @default.
• W2913378097 hasConcept C2779429346 @default.
• W2913378097 hasConcept C2780917455 @default.
• W2913378097 hasConcept C29537977 @default.
• W2913378097 hasConcept C54355233 @default.
• W2913378097 hasConcept C62112901 @default.
• W2913378097 hasConcept C67705224 @default.
• W2913378097 hasConcept C6929976 @default.
• W2913378097 hasConcept C85813293 @default.
• W2913378097 hasConcept C86339819 @default.
• W2913378097 hasConcept C86803240 @default.
• W2913378097 hasConcept C88478588 @default.
• W2913378097 hasConcept C93304396 @default.
• W2913378097 hasConcept C95444343 @default.
• W2913378097 hasConceptScore W2913378097C104317684 @default.
• W2913378097 hasConceptScore W2913378097C1491633281 @default.
• W2913378097 hasConceptScore W2913378097C2777576037 @default.
• W2913378097 hasConceptScore W2913378097C2779419633 @default.
• W2913378097 hasConceptScore W2913378097C2779429346 @default.
• W2913378097 hasConceptScore W2913378097C2780917455 @default.
• W2913378097 hasConceptScore W2913378097C29537977 @default.
• W2913378097 hasConceptScore W2913378097C54355233 @default.
• W2913378097 hasConceptScore W2913378097C62112901 @default.
• W2913378097 hasConceptScore W2913378097C67705224 @default.

• next