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- W2913381522 abstract "Self-assembly is foundational to all life; it is the route by which many important biostructures are formed. Environmental changes which occur together with processes of self-assembly have been shown to dramatically impact the characteristics of the emergent organized structures. Viral capsids are a particularly compelling example of the formation of a biostructure within complex environments. Furthermore, they provide a unique, self-limiting assembly process that can be probed in great detail using computational algorithms. Here, we have employed a coarse-grained computational model to investigate the relationship between viral capsid formation and oscillations in the attractions among its components. It has been demonstrated on similar models in the past that capsid formation is isolated to a narrow range of inter-component attractions under static conditions. However, with our model we observe an oscillation-dependent shift of the range of maximal capsid formation. Our results provide insight into how the complex environmental dynamics within a cell may influence the assembly of essential biological structures." @default.
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- W2913381522 date "2019-02-01" @default.
- W2913381522 modified "2023-09-27" @default.
- W2913381522 title "Self-Assembly of 2D Viral Capsids with Oscillatory Interactions" @default.
- W2913381522 doi "https://doi.org/10.1016/j.bpj.2018.11.3063" @default.
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