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- W2913397279 endingPage "6002" @default.
- W2913397279 startingPage "5979" @default.
- W2913397279 abstract "Medicinal chemists are accountable for embedding the appropriate drug target profile into the molecular architecture of a clinical candidate. An accurate characterization of the functional effects following binding of a drug to its biological target is a fundamental step in the discovery of new medicines, informing the translation of preclinical efficacy and safety observations into human trials. Membrane-bound proteins, particularly ion channels and G protein-coupled receptors (GPCRs), are biological targets prone to allosteric modulation. Investigations using allosteric drug candidates and chemical tools suggest that their functional effects may be tailored with a high degree of translational alignment, making them molecular tools to correct pathophysiological functional tone and enable personalized medicine when a causative target-to-disease link is known. We present select examples of functional molecular fine-tuning of allosterism and discuss consequences relevant to drug design." @default.
- W2913397279 created "2019-02-21" @default.
- W2913397279 creator A5015153470 @default.
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- W2913397279 creator A5047618629 @default.
- W2913397279 creator A5080733102 @default.
- W2913397279 date "2019-02-05" @default.
- W2913397279 modified "2023-10-17" @default.
- W2913397279 title "Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases" @default.
- W2913397279 cites W1235712407 @default.
- W2913397279 cites W133175338 @default.
- W2913397279 cites W1490596873 @default.
- W2913397279 cites W1524500351 @default.
- W2913397279 cites W1556070936 @default.
- W2913397279 cites W1556793322 @default.
- W2913397279 cites W1559266942 @default.
- W2913397279 cites W1856877948 @default.
- W2913397279 cites W1861099460 @default.
- W2913397279 cites W1872072116 @default.
- W2913397279 cites W1884948268 @default.
- W2913397279 cites W1898191473 @default.
- W2913397279 cites W1916899382 @default.
- W2913397279 cites W1964850120 @default.
- W2913397279 cites W1965674436 @default.
- W2913397279 cites W1970095058 @default.
- W2913397279 cites W1971899172 @default.
- W2913397279 cites W1973914285 @default.
- W2913397279 cites W1976266427 @default.
- W2913397279 cites W1991033228 @default.
- W2913397279 cites W1992465104 @default.
- W2913397279 cites W2003926348 @default.
- W2913397279 cites W2005505879 @default.
- W2913397279 cites W2006719424 @default.
- W2913397279 cites W2010993054 @default.
- W2913397279 cites W2012170184 @default.
- W2913397279 cites W2014213356 @default.
- W2913397279 cites W2020348358 @default.
- W2913397279 cites W2020696885 @default.
- W2913397279 cites W2023287752 @default.
- W2913397279 cites W2023615714 @default.
- W2913397279 cites W2036884070 @default.
- W2913397279 cites W2049682677 @default.
- W2913397279 cites W2050512659 @default.
- W2913397279 cites W2057647871 @default.
- W2913397279 cites W2057916169 @default.
- W2913397279 cites W2059401172 @default.
- W2913397279 cites W2061559105 @default.
- W2913397279 cites W2063042770 @default.
- W2913397279 cites W2066514887 @default.
- W2913397279 cites W2067285410 @default.
- W2913397279 cites W2068441555 @default.
- W2913397279 cites W2068632511 @default.
- W2913397279 cites W2071691749 @default.
- W2913397279 cites W2071955997 @default.
- W2913397279 cites W2072346080 @default.
- W2913397279 cites W2083180327 @default.
- W2913397279 cites W2087372220 @default.
- W2913397279 cites W2087387262 @default.
- W2913397279 cites W2087496251 @default.
- W2913397279 cites W2089784535 @default.
- W2913397279 cites W2093640268 @default.
- W2913397279 cites W2093857837 @default.
- W2913397279 cites W2096632965 @default.
- W2913397279 cites W2098439015 @default.
- W2913397279 cites W2099391827 @default.
- W2913397279 cites W2103686849 @default.
- W2913397279 cites W2113285000 @default.
- W2913397279 cites W2113544683 @default.
- W2913397279 cites W2118737630 @default.
- W2913397279 cites W2119698606 @default.
- W2913397279 cites W2123127609 @default.
- W2913397279 cites W2126618993 @default.
- W2913397279 cites W2127546231 @default.
- W2913397279 cites W2134648110 @default.
- W2913397279 cites W2134984814 @default.
- W2913397279 cites W2138603529 @default.
- W2913397279 cites W2141724988 @default.
- W2913397279 cites W2142706899 @default.
- W2913397279 cites W2145736355 @default.
- W2913397279 cites W2150244588 @default.
- W2913397279 cites W2153998112 @default.
- W2913397279 cites W2154119460 @default.
- W2913397279 cites W2158886519 @default.
- W2913397279 cites W2161199046 @default.
- W2913397279 cites W2163153735 @default.
- W2913397279 cites W2164769240 @default.
- W2913397279 cites W2165550831 @default.
- W2913397279 cites W2173841464 @default.
- W2913397279 cites W2191453220 @default.
- W2913397279 cites W2192915718 @default.
- W2913397279 cites W2205777481 @default.
- W2913397279 cites W2239483269 @default.
- W2913397279 cites W2248951706 @default.
- W2913397279 cites W2260891265 @default.
- W2913397279 cites W2274383865 @default.
- W2913397279 cites W2285310363 @default.