Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913397295> ?p ?o ?g. }
- W2913397295 endingPage "754" @default.
- W2913397295 startingPage "742" @default.
- W2913397295 abstract "Upregulation of staphylococcal nuclease domain-containing protein 1 (SND1) is a common phenomenon in different human malignant tissues. However, little information is available on the underlying mechanisms through which SND1 affects glioma cell proliferation and invasion.SND1, Ras homolog family member A (RhoA), and marker of proliferation Ki-67 (MKI67) were analyzed in 187 gliomas by immunostaining. The correlation between those markers and patients' prognoses was assessed using the Kaplan-Meier estimator. Gene Ontology, chromatin immunoprecipitation, electrophoretic mobility shift assay, and chromosome conformation capture were applied to identify SND1-activated target genes. We also used MTT, colony formation, transwell and orthotopic implantation assays to investigate SND1 function in glioma cell proliferative and invasive activity.We identified SND1 and RhoA as independent predictors of poor prognosis in glioma patients. SND1 knockdown significantly suppressed the proliferation and invasion of glioma cells. Mechanistically, we discovered that SND1 facilitated malignant glioma phenotypes by epigenetically inducing chromatin topological interaction, which activated downstream RhoA transcription. RhoA sequentially regulated expression of CCND1, CCNE1, CDK4, and CDKN1B and accelerated G1/S phase transition in glioma cell proliferation.Our findings identify SND1 as a novel chromatin architectural modifier and promising prognostic indicator for glioma classification and treatment." @default.
- W2913397295 created "2019-02-21" @default.
- W2913397295 creator A5015235892 @default.
- W2913397295 creator A5021380919 @default.
- W2913397295 creator A5035088841 @default.
- W2913397295 creator A5035282947 @default.
- W2913397295 creator A5036339709 @default.
- W2913397295 creator A5043104044 @default.
- W2913397295 creator A5046225712 @default.
- W2913397295 creator A5056606390 @default.
- W2913397295 creator A5059109520 @default.
- W2913397295 creator A5063293101 @default.
- W2913397295 creator A5082950148 @default.
- W2913397295 creator A5083795631 @default.
- W2913397295 date "2019-02-12" @default.
- W2913397295 modified "2023-10-17" @default.
- W2913397295 title "The novel chromatin architectural regulator SND1 promotes glioma proliferation and invasion and predicts the prognosis of patients" @default.
- W2913397295 cites W1507216163 @default.
- W2913397295 cites W1825871834 @default.
- W2913397295 cites W1919521267 @default.
- W2913397295 cites W1978660339 @default.
- W2913397295 cites W1985213868 @default.
- W2913397295 cites W1990450828 @default.
- W2913397295 cites W1996868531 @default.
- W2913397295 cites W2043702724 @default.
- W2913397295 cites W2051747485 @default.
- W2913397295 cites W2054080830 @default.
- W2913397295 cites W2055475004 @default.
- W2913397295 cites W2059624809 @default.
- W2913397295 cites W2064582293 @default.
- W2913397295 cites W2064957005 @default.
- W2913397295 cites W2073685814 @default.
- W2913397295 cites W2085470111 @default.
- W2913397295 cites W2095720556 @default.
- W2913397295 cites W2123811677 @default.
- W2913397295 cites W2130923210 @default.
- W2913397295 cites W2132886470 @default.
- W2913397295 cites W2154907940 @default.
- W2913397295 cites W2264115069 @default.
- W2913397295 cites W2318304207 @default.
- W2913397295 cites W2366536035 @default.
- W2913397295 cites W2521652730 @default.
- W2913397295 cites W2592123165 @default.
- W2913397295 cites W2605899767 @default.
- W2913397295 cites W2791600443 @default.
- W2913397295 cites W2795377613 @default.
- W2913397295 cites W2806328383 @default.
- W2913397295 cites W2807096124 @default.
- W2913397295 cites W2884317945 @default.
- W2913397295 cites W2889234025 @default.
- W2913397295 doi "https://doi.org/10.1093/neuonc/noz038" @default.
- W2913397295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6556862" @default.
- W2913397295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30753603" @default.
- W2913397295 hasPublicationYear "2019" @default.
- W2913397295 type Work @default.
- W2913397295 sameAs 2913397295 @default.
- W2913397295 citedByCount "17" @default.
- W2913397295 countsByYear W29133972952019 @default.
- W2913397295 countsByYear W29133972952020 @default.
- W2913397295 countsByYear W29133972952021 @default.
- W2913397295 countsByYear W29133972952022 @default.
- W2913397295 countsByYear W29133972952023 @default.
- W2913397295 crossrefType "journal-article" @default.
- W2913397295 hasAuthorship W2913397295A5015235892 @default.
- W2913397295 hasAuthorship W2913397295A5021380919 @default.
- W2913397295 hasAuthorship W2913397295A5035088841 @default.
- W2913397295 hasAuthorship W2913397295A5035282947 @default.
- W2913397295 hasAuthorship W2913397295A5036339709 @default.
- W2913397295 hasAuthorship W2913397295A5043104044 @default.
- W2913397295 hasAuthorship W2913397295A5046225712 @default.
- W2913397295 hasAuthorship W2913397295A5056606390 @default.
- W2913397295 hasAuthorship W2913397295A5059109520 @default.
- W2913397295 hasAuthorship W2913397295A5063293101 @default.
- W2913397295 hasAuthorship W2913397295A5082950148 @default.
- W2913397295 hasAuthorship W2913397295A5083795631 @default.
- W2913397295 hasBestOaLocation W29133972951 @default.
- W2913397295 hasConcept C101762097 @default.
- W2913397295 hasConcept C104317684 @default.
- W2913397295 hasConcept C121608353 @default.
- W2913397295 hasConcept C126322002 @default.
- W2913397295 hasConcept C127561419 @default.
- W2913397295 hasConcept C134320426 @default.
- W2913397295 hasConcept C1491633281 @default.
- W2913397295 hasConcept C150194340 @default.
- W2913397295 hasConcept C173396325 @default.
- W2913397295 hasConcept C2777093181 @default.
- W2913397295 hasConcept C2778227246 @default.
- W2913397295 hasConcept C29537977 @default.
- W2913397295 hasConcept C502942594 @default.
- W2913397295 hasConcept C54355233 @default.
- W2913397295 hasConcept C555283112 @default.
- W2913397295 hasConcept C62112901 @default.
- W2913397295 hasConcept C62478195 @default.
- W2913397295 hasConcept C71924100 @default.
- W2913397295 hasConcept C83640560 @default.
- W2913397295 hasConcept C86803240 @default.
- W2913397295 hasConcept C95444343 @default.
- W2913397295 hasConceptScore W2913397295C101762097 @default.