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• W2913399638 abstract "Abstract Introduction Mycobacterium simiae is an emerging pathogen in Iran and little is known about drug susceptibility patterns of this pathogen. Materials and methods Twenty five clinical isolates of M. simiae from 80 patients with confirmed NTM pulmonary disease were included in this study. For drug susceptibility testing (DST), proportional and broth microdilution methods were used according to the clinical and laboratory standards institute (CLSI) guideline. Results All clinical isolates of M. simiae were resistant to isoniazid, rifampicin, ethambutol, streptomycin, amikacin, kanamycin, ciprofloxacin and clarithromycin. They also were highly resistant to ofloxacin (80%). Susceptibility to ofloxacin was only noted in the 5 isolates. Conclusions Clinical isolates of M. simiae were multidrug resistant, and had different drug susceptibility patterns than previously published studies. DST results can assist in selecting more appropriate treatment regimens. Newer drugs with proven clinical efficacy correlating with in vitro susceptibility should be substituted with first- and second line anti-TB drug testing. Author summary Mycobacterium simiae can cause serious pulmonary diseases. It has been recognized as an emerging pathogen in Iran. Although few cases have been reported, M. simiae has been associated with multidrug-resistance. In our study, we have observed a surprisingly high proportion of highly drug-resistant M. simiae. This data call for a scale-up of TB control program in Iran." @default.
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• W2913399638 date "2019-08-31" @default.
• W2913399638 modified "2023-09-23" @default.
• W2913399638 title "Drug susceptibility testing of Mycobacterium simiae: An emerging pathogen in Iran" @default.
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