FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913403208> ?p ?o ?g. }

• W2913403208 endingPage "752" @default.
• W2913403208 startingPage "739" @default.
• W2913403208 abstract "This study aimed to identify potential biomarkers for primary open-angle glaucoma (POAG) diagnosis. First, long noncoding RNA (lncRNA) and mRNA expression profiles in the aqueous humor (AH) from 10 POAG and 10 control patients were accessed by microarray analyses. Coding-noncoding gene coexpression networks were drawn to predict potential lncRNA functions. lncRNA T267384, ENST00000607393, and T342877 expression levels were further tested by real-time quantitative PCR in AH from 29 POAG and 30 cataract patients, in iris tissues from 16 POAG patients and 10 controls, and in plasma from 49 POAG patients and 55 healthy controls. Finally, ENST00000607393 function was characterized in an in vitro model of cell calcification. A total of 3627 lncRNAs and 2228 mRNAs in the AH of POAG patients were significantly up-regulated, and 1520 lncRNAs and 820 mRNAs were significantly down-regulated. Seven lncRNAs showed positive correlation with glaucoma-associated gene, bone morphogenetic protein 2. Moreover, real-time quantitative RT-PCR confirmed that T267384, ENST00000607393, and T342877 expression levels were significantly higher in the AH from a different cohort of POAG patients. ENST00000607393 was also significantly higher in the iris and plasma of POAG patients. Last, ENST00000607393 knockdown alleviated calcification of primary human trabecular meshwork cells in vitro. Therefore, lncRNAs T267384, ENST00000607393, and T342877 may be potential biomarkers for POAG diagnosis. ENST00000607393 might be a new therapeutic target for trabecular meshwork calcification." @default.
• W2913403208 created "2019-02-21" @default.
• W2913403208 creator A5016460624 @default.
• W2913403208 creator A5037825847 @default.
• W2913403208 creator A5039938158 @default.
• W2913403208 creator A5040852129 @default.
• W2913403208 creator A5046078938 @default.
• W2913403208 creator A5060113796 @default.
• W2913403208 creator A5075609639 @default.
• W2913403208 creator A5077781746 @default.
• W2913403208 creator A5077917267 @default.
• W2913403208 date "2019-04-01" @default.
• W2913403208 modified "2023-10-17" @default.
• W2913403208 title "Potential Biomarkers for Primary Open-Angle Glaucoma Identified by Long Noncoding RNA Profiling in the Aqueous Humor" @default.
• W2913403208 cites W1518691641 @default.
• W2913403208 cites W1832616244 @default.
• W2913403208 cites W1849111649 @default.
• W2913403208 cites W1938512613 @default.
• W2913403208 cites W1968210590 @default.
• W2913403208 cites W1970320378 @default.
• W2913403208 cites W1970882491 @default.
• W2913403208 cites W1978986405 @default.
• W2913403208 cites W2015310445 @default.
• W2913403208 cites W2018787145 @default.
• W2913403208 cites W2020967333 @default.
• W2913403208 cites W2021574276 @default.
• W2913403208 cites W2033105460 @default.
• W2913403208 cites W2041612070 @default.
• W2913403208 cites W2044601473 @default.
• W2913403208 cites W2046361674 @default.
• W2913403208 cites W2047830315 @default.
• W2913403208 cites W2049883153 @default.
• W2913403208 cites W2057266151 @default.
• W2913403208 cites W2060246867 @default.
• W2913403208 cites W2066567696 @default.
• W2913403208 cites W2069543726 @default.
• W2913403208 cites W2074206215 @default.
• W2913403208 cites W2082354759 @default.
• W2913403208 cites W2087070388 @default.
• W2913403208 cites W2095137869 @default.
• W2913403208 cites W2110986932 @default.
• W2913403208 cites W2116703462 @default.
• W2913403208 cites W2138884188 @default.
• W2913403208 cites W2138974073 @default.
• W2913403208 cites W2142019735 @default.
• W2913403208 cites W2151459533 @default.
• W2913403208 cites W2159675211 @default.
• W2913403208 cites W2175207930 @default.
• W2913403208 cites W2193435616 @default.
• W2913403208 cites W2262738269 @default.
• W2913403208 cites W2265211195 @default.
• W2913403208 cites W2265638154 @default.
• W2913403208 cites W2267639294 @default.
• W2913403208 cites W2287764170 @default.
• W2913403208 cites W2292889165 @default.
• W2913403208 cites W2317958404 @default.
• W2913403208 cites W2334881644 @default.
• W2913403208 cites W2336697091 @default.
• W2913403208 cites W2343938601 @default.
• W2913403208 cites W2475033908 @default.
• W2913403208 cites W2505384565 @default.
• W2913403208 cites W2517842986 @default.
• W2913403208 cites W2535670715 @default.
• W2913403208 cites W2563577205 @default.
• W2913403208 cites W2594956929 @default.
• W2913403208 cites W2604210246 @default.
• W2913403208 cites W2612979765 @default.
• W2913403208 cites W2615160023 @default.
• W2913403208 cites W2621020647 @default.
• W2913403208 cites W2625283862 @default.
• W2913403208 cites W2733972655 @default.
• W2913403208 cites W2743186002 @default.
• W2913403208 cites W2753719005 @default.
• W2913403208 cites W2763759608 @default.
• W2913403208 cites W2775133488 @default.
• W2913403208 cites W2783987800 @default.
• W2913403208 cites W2791835785 @default.
• W2913403208 cites W2793740592 @default.
• W2913403208 cites W4206485229 @default.
• W2913403208 doi "https://doi.org/10.1016/j.ajpath.2018.12.011" @default.
• W2913403208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30677397" @default.
• W2913403208 hasPublicationYear "2019" @default.
• W2913403208 type Work @default.
• W2913403208 sameAs 2913403208 @default.
• W2913403208 citedByCount "23" @default.
• W2913403208 countsByYear W29134032082019 @default.
• W2913403208 countsByYear W29134032082020 @default.
• W2913403208 countsByYear W29134032082021 @default.
• W2913403208 countsByYear W29134032082022 @default.
• W2913403208 countsByYear W29134032082023 @default.
• W2913403208 crossrefType "journal-article" @default.
• W2913403208 hasAuthorship W2913403208A5016460624 @default.
• W2913403208 hasAuthorship W2913403208A5037825847 @default.
• W2913403208 hasAuthorship W2913403208A5039938158 @default.
• W2913403208 hasAuthorship W2913403208A5040852129 @default.
• W2913403208 hasAuthorship W2913403208A5046078938 @default.
• W2913403208 hasAuthorship W2913403208A5060113796 @default.
• W2913403208 hasAuthorship W2913403208A5075609639 @default.

• next