Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913405142> ?p ?o ?g. }
- W2913405142 endingPage "4444" @default.
- W2913405142 startingPage "4435" @default.
- W2913405142 abstract "Nanoparticles (NP) in biological fluids almost invariably become coated with proteins to form protein coronas. It is the NP-protein corona rather than the bare nanoparticle that determines the nanoparticle's bio-behavior. Here, ultrasmall gold nanoparticles (AuNPs) coated by a human serum albumin (HSA) corona were studied by Fourier transform infrared spectroscopy, denature experiments, fluorescence quenching. Moreover, the intracellular fate of AuNPs and the AuNP-HSA corona has also been investigated. The results show that HSA corona undergo a conformational transition (partial β-sheet changed to α-helicity) when they adsorb on AuNPs, which lead to an enhanced thermal stability. Importantly, we observed that the conformation-transited protein corona-AuNP complex could induce cell apoptosis. Meanwhile, for the first time, the conformation-transited HSA on the AuNPs surface are shown to disrupt living cell membranes. The results obtained here not only provide the detailed conformational behavior of HSA molecules on nanoparticles, but also reveal the structure-function relationship of protein corona, which is of utmost importance in the safe application of nanoscale objects in living organisms." @default.
- W2913405142 created "2019-02-21" @default.
- W2913405142 creator A5011860975 @default.
- W2913405142 creator A5026453778 @default.
- W2913405142 creator A5036726873 @default.
- W2913405142 creator A5069693179 @default.
- W2913405142 creator A5073824709 @default.
- W2913405142 creator A5076097117 @default.
- W2913405142 creator A5081844561 @default.
- W2913405142 creator A5087078478 @default.
- W2913405142 date "2019-01-01" @default.
- W2913405142 modified "2023-10-17" @default.
- W2913405142 title "Conformational-transited protein corona regulated cell-membrane penetration and induced cytotoxicity of ultrasmall Au nanoparticles" @default.
- W2913405142 cites W1500322150 @default.
- W2913405142 cites W1504792186 @default.
- W2913405142 cites W161940758 @default.
- W2913405142 cites W1902894346 @default.
- W2913405142 cites W1963565300 @default.
- W2913405142 cites W1973387903 @default.
- W2913405142 cites W1980065701 @default.
- W2913405142 cites W1982074128 @default.
- W2913405142 cites W1984364967 @default.
- W2913405142 cites W1990796256 @default.
- W2913405142 cites W1992045220 @default.
- W2913405142 cites W1994293164 @default.
- W2913405142 cites W2001199187 @default.
- W2913405142 cites W2002528172 @default.
- W2913405142 cites W2012386674 @default.
- W2913405142 cites W2022203941 @default.
- W2913405142 cites W2038246612 @default.
- W2913405142 cites W2044252957 @default.
- W2913405142 cites W2044257767 @default.
- W2913405142 cites W2046890107 @default.
- W2913405142 cites W2049979253 @default.
- W2913405142 cites W2050514733 @default.
- W2913405142 cites W2052130118 @default.
- W2913405142 cites W2055553682 @default.
- W2913405142 cites W2056505159 @default.
- W2913405142 cites W2057910069 @default.
- W2913405142 cites W2060878281 @default.
- W2913405142 cites W2065622824 @default.
- W2913405142 cites W2073964150 @default.
- W2913405142 cites W2075409966 @default.
- W2913405142 cites W2075705506 @default.
- W2913405142 cites W2077142078 @default.
- W2913405142 cites W2090757591 @default.
- W2913405142 cites W2091584330 @default.
- W2913405142 cites W2102264945 @default.
- W2913405142 cites W2107735396 @default.
- W2913405142 cites W2108615682 @default.
- W2913405142 cites W2110634891 @default.
- W2913405142 cites W2115873485 @default.
- W2913405142 cites W2117470753 @default.
- W2913405142 cites W2119265369 @default.
- W2913405142 cites W2122046010 @default.
- W2913405142 cites W2140234721 @default.
- W2913405142 cites W2152469683 @default.
- W2913405142 cites W2158138220 @default.
- W2913405142 cites W2158558808 @default.
- W2913405142 cites W2167362634 @default.
- W2913405142 cites W2172683812 @default.
- W2913405142 cites W2284550715 @default.
- W2913405142 cites W2313067117 @default.
- W2913405142 cites W2328483829 @default.
- W2913405142 cites W2330988713 @default.
- W2913405142 cites W2402319960 @default.
- W2913405142 cites W2536895340 @default.
- W2913405142 cites W2588703017 @default.
- W2913405142 cites W2595570848 @default.
- W2913405142 cites W2604011813 @default.
- W2913405142 cites W2605342716 @default.
- W2913405142 cites W2617232863 @default.
- W2913405142 cites W2749911740 @default.
- W2913405142 cites W2773580742 @default.
- W2913405142 cites W2788364246 @default.
- W2913405142 cites W2801800203 @default.
- W2913405142 cites W2807448578 @default.
- W2913405142 cites W2896625042 @default.
- W2913405142 cites W2900200308 @default.
- W2913405142 cites W4230940536 @default.
- W2913405142 cites W575177823 @default.
- W2913405142 doi "https://doi.org/10.1039/c8ra10049g" @default.
- W2913405142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35520163" @default.
- W2913405142 hasPublicationYear "2019" @default.
- W2913405142 type Work @default.
- W2913405142 sameAs 2913405142 @default.
- W2913405142 citedByCount "20" @default.
- W2913405142 countsByYear W29134051422020 @default.
- W2913405142 countsByYear W29134051422021 @default.
- W2913405142 countsByYear W29134051422022 @default.
- W2913405142 countsByYear W29134051422023 @default.
- W2913405142 crossrefType "journal-article" @default.
- W2913405142 hasAuthorship W2913405142A5011860975 @default.
- W2913405142 hasAuthorship W2913405142A5026453778 @default.
- W2913405142 hasAuthorship W2913405142A5036726873 @default.
- W2913405142 hasAuthorship W2913405142A5069693179 @default.
- W2913405142 hasAuthorship W2913405142A5073824709 @default.
- W2913405142 hasAuthorship W2913405142A5076097117 @default.