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• W2913411516 abstract "Single-molecule picometer resolution nanopore tweezers (SPRNT) is a single-molecule technique that enables observation of enzyme movement along nucleic acids under an applied force. SPRNT measures enzyme position with sub-Angstrom spatial and millisecond temporal resolution, while simultaneously providing DNA sequence within the enzyme. We use SPRNT to monitor many E. coli RNA Polymerase (RNAP) core complexes during transcription elongation and pausing with an assisting force. We determine that during elongation at low [NTP], RNAP primarily stalls in a post-translocated state, with brief deviations forward to a hyper-translocated state and backwards to a pre-translocated state. The rates and frequencies of these transitions vary with DNA sequence. During transcription pausing at a pre-determined pause sequence, we observe RNAP entering a partially-translocated state, with brief deviations to backtracked, pre-, post- and hyper-translocated states. We develop a model for RNAP pausing by varying the applied force and monitoring RNAP mutants with SPRNT." @default.
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• W2913411516 date "2019-02-01" @default.
• W2913411516 modified "2023-09-27" @default.
• W2913411516 title "Determining Dynamics of RNA Polymerase Elongation and Pausing using Nanopore Tweezers" @default.
• W2913411516 doi "https://doi.org/10.1016/j.bpj.2018.11.1152" @default.
• W2913411516 hasPublicationYear "2019" @default.
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