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• W2913426265 abstract "Psoriasis (PS) is a systemic, immune-mediated inflammatory disorder. However, the whole lymphocyte compartment and the potential pathologies of PS have not been fully characterized. In the present study, we examined whole lymphocyte subsets and signal transduction proteins using high-dimensional single-cell mass cytometry and a bioinformatics pipeline for an in-depth characterization of the immune cell subsets and protein profiles involved in pathways in the peripheral blood of patients with PS. We identified 15 major immune cell populations in T cell lineages and characterized various CD3+CD4+ Th and CD3+CD8+ T cytotoxic cell populations simultaneously across 24 leukocyte markers and 7 proteins related to the signal transduction pathways. High-dimensional analysis identified 3 new subsets that are abundant in PS peripheral blood, resembling CD3-CD4+ lymphoid tissue inducer cells, Tc17 cells, and CD8+CXCR3+ Tregs. We confirmed the CD3-CD4+ cells, and their features and functions, in an independent PS cohort. The use of single-cell mass cytometry allows systemic-level characterization of lymphocyte subpopulations and dysregulated signaling pathways in the blood of patients with PS, identifying abnormalities of different immune cell subsets. We validated that the CD3-CD4+ cells had elevated OX40 and decreased FRA2 expression, which were positively associated with the PS area and severity index." @default.
• W2913426265 created "2019-02-21" @default.
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• W2913426265 date "2019-02-12" @default.
• W2913426265 modified "2023-10-12" @default.
• W2913426265 title "Lymphocyte mass cytometry identifies a CD3-CD4+ cells subset with a potential role in psoriasis" @default.
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• W2913426265 doi "https://doi.org/10.1172/jci.insight.125306" @default.
• W2913426265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6483065" @default.
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