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- W2913440981 endingPage "471" @default.
- W2913440981 startingPage "459" @default.
- W2913440981 abstract "Alzheimer’s disease (AD), the most common type of dementia worldwide, is characterized by high levels of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Genetically, the ɛ4 allele of apolipoprotein E (ApoE) has been established as the major risk factor for developing late-onset AD (LOAD ), the most common form of the disease. Although the role ApoE plays in AD is still not completely understood, a differential role of its isoforms has long been known. The current review compiles the involvement of ApoE isoforms in amyloid-β protein precursor transcription, Aβ aggregation and clearance, synaptic plasticity, neuroinflammation, lipid metabolism, mitochondrial function, and tau hyperphosphorylation. Due to the complexity of LOAD, an accurate description of the interdependence among all the related molecular mechanisms involved in the disease is needed for developing successful therapies." @default.
- W2913440981 created "2019-02-21" @default.
- W2913440981 creator A5048578939 @default.
- W2913440981 creator A5056197299 @default.
- W2913440981 creator A5061996148 @default.
- W2913440981 date "2019-03-29" @default.
- W2913440981 modified "2023-09-25" @default.
- W2913440981 title "The Role of Apolipoprotein E Isoforms in Alzheimer’s Disease" @default.
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