FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913441707> ?p ?o ?g. }

• W2913441707 endingPage "57" @default.
• W2913441707 startingPage "45" @default.
• W2913441707 abstract "Cystic fibrosis-related diabetes (CFRD) is a common complication for patients with cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). The cause of CFRD is unclear, but a commonly observed reduction in first-phase insulin secretion suggests defects at the beta cell level. Here we aimed to examine alpha and beta cell function in the Cftr tm1 EUR /F508del mouse model (C57BL/6J), which carries the most common human mutation in CFTR , the F508del mutation. CFTR expression, beta cell mass, insulin granule distribution, hormone secretion and single cell capacitance changes were evaluated using islets (or beta cells) from F508del mice and age-matched wild type (WT) mice aged 7–10 weeks. Granular pH was measured with DND-189 fluorescence. Serum glucose, insulin and glucagon levels were measured in vivo , and glucose tolerance was assessed using IPGTT. We show increased secretion of proinsulin and concomitant reduced secretion of C-peptide in islets from F508del mice compared to WT mice. Exocytosis and number of docked granules was reduced. We confirmed reduced granular pH by CFTR stimulation. We detected decreased pancreatic beta cell area, but unchanged beta cell number. Moreover, the F508del mutation caused failure to suppress glucagon secretion leading to hyperglucagonemia. In conclusion, F508del mice have beta cell defects resulting in (1) reduced number of docked insulin granules and reduced exocytosis and (2) potential defective proinsulin cleavage and secretion of immature insulin. These observations provide insight into the functional role of CFTR in pancreatic islets and contribute to increased understanding of the pathogenesis of CFRD." @default.
• W2913441707 created "2019-02-21" @default.
• W2913441707 creator A5019916793 @default.
• W2913441707 creator A5028584928 @default.
• W2913441707 creator A5029095902 @default.
• W2913441707 creator A5031280886 @default.
• W2913441707 creator A5033038377 @default.
• W2913441707 creator A5047082709 @default.
• W2913441707 creator A5048449665 @default.
• W2913441707 creator A5059473128 @default.
• W2913441707 creator A5063022001 @default.
• W2913441707 creator A5063133241 @default.
• W2913441707 creator A5068418631 @default.
• W2913441707 creator A5068926509 @default.
• W2913441707 creator A5083483735 @default.
• W2913441707 creator A5091244301 @default.
• W2913441707 date "2019-04-01" @default.
• W2913441707 modified "2023-10-17" @default.
• W2913441707 title "Defective exocytosis and processing of insulin in a cystic fibrosis mouse model" @default.
• W2913441707 cites W1503660683 @default.
• W2913441707 cites W1559981541 @default.
• W2913441707 cites W1589179363 @default.
• W2913441707 cites W1745204207 @default.
• W2913441707 cites W1963953120 @default.
• W2913441707 cites W1979472853 @default.
• W2913441707 cites W1985619693 @default.
• W2913441707 cites W1992753036 @default.
• W2913441707 cites W1993088180 @default.
• W2913441707 cites W2004564781 @default.
• W2913441707 cites W2010496061 @default.
• W2913441707 cites W2029600756 @default.
• W2913441707 cites W2030600480 @default.
• W2913441707 cites W2032595821 @default.
• W2913441707 cites W2036052397 @default.
• W2913441707 cites W2041346929 @default.
• W2913441707 cites W2054750378 @default.
• W2913441707 cites W2059516713 @default.
• W2913441707 cites W2062305588 @default.
• W2913441707 cites W2064286821 @default.
• W2913441707 cites W2078818437 @default.
• W2913441707 cites W2081092314 @default.
• W2913441707 cites W2089942817 @default.
• W2913441707 cites W2090607771 @default.
• W2913441707 cites W2095195470 @default.
• W2913441707 cites W2095268130 @default.
• W2913441707 cites W2100735012 @default.
• W2913441707 cites W2103920106 @default.
• W2913441707 cites W2104890139 @default.
• W2913441707 cites W2106997862 @default.
• W2913441707 cites W2125240189 @default.
• W2913441707 cites W2126153001 @default.
• W2913441707 cites W2133217243 @default.
• W2913441707 cites W2137623756 @default.
• W2913441707 cites W2144387356 @default.
• W2913441707 cites W2146114441 @default.
• W2913441707 cites W2147821592 @default.
• W2913441707 cites W2164561590 @default.
• W2913441707 cites W2165967175 @default.
• W2913441707 cites W2167789521 @default.
• W2913441707 cites W2172574503 @default.
• W2913441707 cites W2321266618 @default.
• W2913441707 cites W2323900459 @default.
• W2913441707 cites W2387687895 @default.
• W2913441707 cites W2484917035 @default.
• W2913441707 cites W2498257067 @default.
• W2913441707 cites W2523369352 @default.
• W2913441707 cites W2592847274 @default.
• W2913441707 cites W2736452323 @default.
• W2913441707 cites W2738293628 @default.
• W2913441707 cites W2757711168 @default.
• W2913441707 cites W2802569467 @default.
• W2913441707 cites W2807014976 @default.
• W2913441707 cites W2888375595 @default.
• W2913441707 cites W9542571 @default.
• W2913441707 doi "https://doi.org/10.1530/joe-18-0570" @default.
• W2913441707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721137" @default.
• W2913441707 hasPublicationYear "2019" @default.
• W2913441707 type Work @default.
• W2913441707 sameAs 2913441707 @default.
• W2913441707 citedByCount "14" @default.
• W2913441707 countsByYear W29134417072019 @default.
• W2913441707 countsByYear W29134417072021 @default.
• W2913441707 countsByYear W29134417072022 @default.
• W2913441707 countsByYear W29134417072023 @default.
• W2913441707 crossrefType "journal-article" @default.
• W2913441707 hasAuthorship W2913441707A5019916793 @default.
• W2913441707 hasAuthorship W2913441707A5028584928 @default.
• W2913441707 hasAuthorship W2913441707A5029095902 @default.
• W2913441707 hasAuthorship W2913441707A5031280886 @default.
• W2913441707 hasAuthorship W2913441707A5033038377 @default.
• W2913441707 hasAuthorship W2913441707A5047082709 @default.
• W2913441707 hasAuthorship W2913441707A5048449665 @default.
• W2913441707 hasAuthorship W2913441707A5059473128 @default.
• W2913441707 hasAuthorship W2913441707A5063022001 @default.
• W2913441707 hasAuthorship W2913441707A5063133241 @default.
• W2913441707 hasAuthorship W2913441707A5068418631 @default.
• W2913441707 hasAuthorship W2913441707A5068926509 @default.
• W2913441707 hasAuthorship W2913441707A5083483735 @default.

• next