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- W2913441745 endingPage "938" @default.
- W2913441745 startingPage "926" @default.
- W2913441745 abstract "Diabetic neuropathy is a multisystem disorder with protean manifestations. Pathologic study of a disease provides insights into the precise mechanisms and targets of damage and may provide insights into new therapies. The main targets in diabetic neuropathy are myelinated and unmyelinated fibers as dysfunction and damage to these explains the symptoms of painful neuropathy and the major endpoints of foot ulceration and amputation as well as mortality. Demyelination and axonal degeneration are established hallmarks of the pathology of human diabetic neuropathy and were derived from pioneering light and electronmicroscopic studies of sural nerve biopsies in the late 1960s and early 1970s. The early part of this century witnessed the introduction of intraepidermal nerve quantification in skin biopsies, which has provided a minimally invasive means for the early diagnosis of diabetic neuropathy. More recently translational work from ophthalmology has revolutionized our ability to diagnose, stratify severity, and determine the benefits of therapeutic intervention in diabetic and other peripheral neuropathies using the novel noninvasive technique of corneal confocal microscopy." @default.
- W2913441745 created "2019-02-21" @default.
- W2913441745 creator A5048652023 @default.
- W2913441745 creator A5061524115 @default.
- W2913441745 creator A5082381093 @default.
- W2913441745 date "2015-03-06" @default.
- W2913441745 modified "2023-10-16" @default.
- W2913441745 title "Pathology of human diabetic neuropathy" @default.
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