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• W2913442059 abstract "In recent years, systemic hypothermia has taken the spotlight for its use in spinal cord injury (SCI) research fields, but detailed molecular mechanisms are still not fully understood. In this study, we use an online-electrochemical system (OECS) to in vivo continuously monitor the ascorbate of the rats’ spinal cord. We find that the basal level of ascorbate in rat spinal cord is 1.85 ± 0.88 μmol L−1 (n = 20). It increased immediately after SCI and reached 2.36 ± 0.65 μmol L−1 (164.90% ± 7.99% of the basal level) (n = 5) at 60 min after the injury. The SCI-induced extracellular ascorbate increase is obviously attenuated by therapeutic hypothermia (28 °C) after injury and ascorbate returns to 3.01 ± 0.59 μmol L−1 (100.24% ± 5.02% of the basal level) (n = 5), at 60 min after SCI. These results substantially manifest that the OECS for ascorbate detection could be employed as a platform for understanding the pathological changes during spinal cord injury. This study provides experimental evidence for the essential roles of ascorbate in SCI which could serve as a biomarker for SCI. Our findings also raise the possibility that therapeutic hypothermia can effectively exert neuroprotection in the acute phase of SCI." @default.
• W2913442059 created "2019-02-21" @default.
• W2913442059 creator A5001118446 @default.
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• W2913442059 date "2018-12-11" @default.
• W2913442059 modified "2023-09-23" @default.
• W2913442059 title "Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury" @default.
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• W2913442059 doi "https://doi.org/10.1080/21691401.2018.1541136" @default.
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