Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913448064> ?p ?o ?g. }
- W2913448064 endingPage "e000763" @default.
- W2913448064 startingPage "e000763" @default.
- W2913448064 abstract "Objective The objective was to investigate the short-term risk of major adverse cardiovascular events (MACEs) or congestive heart failure (CHF) in patients with psoriatic arthritis (PsA) or psoriasis initiating a biological therapy. Methods Screening for the study was carried out using MEDLINE, Cochrane and Embase, from the inception of the database to December 2017. Randomised controlled trials (RCTs) of anti-tumour necrosis factor (TNF), anti-interleukin (IL)12/23, anti-IL23 and anti-IL17 agents for the treatment of PsA or psoriasis were included. Two investigators independently extracted MACEs or CHF data reported during the placebo-controlled phase. The primary outcome measures were the incidence of MACEs or CHF. Results Of 753 references screened, 62 articles were selected, and 12 articles were added by manual searches. Accordingly 77 RCTs were included in the meta-analysis (MA) (10 174 patient-years (P-Y)). No significant difference was observed in MACE incidences in patients receiving anti-TNF, anti-IL12/23, anti-IL23 or anti-IL17 agents in comparison to the placebo. However, 10 MACEs were observed in the anti-IL12/23 group (1150 P-Y) compared with 1 in the placebo group (652 P-Y), with 0.01 −0.00 to 0.02 event/P-Y risk difference, which is not statistically significant. This trend was not observed in the anti-IL23 group. No significant difference was observed in CHF incidence in patients receiving biological agents in comparison to placebo. Conclusion This MA of 77 RCTs did not reveal any significant change in the short-term risk of MACE or CHF in patients with PsA or psoriasis initiating a biological therapy." @default.
- W2913448064 created "2019-02-21" @default.
- W2913448064 creator A5018478650 @default.
- W2913448064 creator A5024483501 @default.
- W2913448064 creator A5033486865 @default.
- W2913448064 creator A5039399346 @default.
- W2913448064 creator A5074863723 @default.
- W2913448064 creator A5086550404 @default.
- W2913448064 date "2019-01-01" @default.
- W2913448064 modified "2023-10-05" @default.
- W2913448064 title "Short-term risk of major adverse cardiovascular events or congestive heart failure in patients with psoriatic arthritis or psoriasis initiating a biological therapy: a meta–analysis of randomised controlled trials" @default.
- W2913448064 cites W1500119734 @default.
- W2913448064 cites W1508752722 @default.
- W2913448064 cites W1541270304 @default.
- W2913448064 cites W1572018981 @default.
- W2913448064 cites W1661616496 @default.
- W2913448064 cites W1845936179 @default.
- W2913448064 cites W1909750378 @default.
- W2913448064 cites W1922566561 @default.
- W2913448064 cites W1924457352 @default.
- W2913448064 cites W1931293371 @default.
- W2913448064 cites W1935617463 @default.
- W2913448064 cites W1973354423 @default.
- W2913448064 cites W1975463338 @default.
- W2913448064 cites W1978824248 @default.
- W2913448064 cites W1998976412 @default.
- W2913448064 cites W2003687140 @default.
- W2913448064 cites W2005176759 @default.
- W2913448064 cites W2008716526 @default.
- W2913448064 cites W2013361256 @default.
- W2913448064 cites W2015099427 @default.
- W2913448064 cites W2015504883 @default.
- W2913448064 cites W2023039127 @default.
- W2913448064 cites W2023733075 @default.
- W2913448064 cites W2030348118 @default.
- W2913448064 cites W2031157372 @default.
- W2913448064 cites W2053127888 @default.
- W2913448064 cites W2056361036 @default.
- W2913448064 cites W2061084002 @default.
- W2913448064 cites W2071343804 @default.
- W2913448064 cites W2080390872 @default.
- W2913448064 cites W2088155036 @default.
- W2913448064 cites W2091442391 @default.
- W2913448064 cites W2094124191 @default.
- W2913448064 cites W2095756367 @default.
- W2913448064 cites W2097973532 @default.
- W2913448064 cites W2099687194 @default.
- W2913448064 cites W2103499669 @default.
- W2913448064 cites W2103524303 @default.
- W2913448064 cites W2103750969 @default.
- W2913448064 cites W2108984264 @default.
- W2913448064 cites W2115041506 @default.
- W2913448064 cites W2116956799 @default.
- W2913448064 cites W2118322865 @default.
- W2913448064 cites W2126798127 @default.
- W2913448064 cites W2127834887 @default.
- W2913448064 cites W2133696182 @default.
- W2913448064 cites W2137101132 @default.
- W2913448064 cites W2138647255 @default.
- W2913448064 cites W2145778588 @default.
- W2913448064 cites W2146843653 @default.
- W2913448064 cites W2149168537 @default.
- W2913448064 cites W2151209321 @default.
- W2913448064 cites W2151280501 @default.
- W2913448064 cites W2155648467 @default.
- W2913448064 cites W2163232748 @default.
- W2913448064 cites W2164533070 @default.
- W2913448064 cites W2167795826 @default.
- W2913448064 cites W2168505126 @default.
- W2913448064 cites W2168698481 @default.
- W2913448064 cites W2168911501 @default.
- W2913448064 cites W2169773326 @default.
- W2913448064 cites W2171889601 @default.
- W2913448064 cites W2172257129 @default.
- W2913448064 cites W2194197257 @default.
- W2913448064 cites W2254568118 @default.
- W2913448064 cites W2322390243 @default.
- W2913448064 cites W2326643498 @default.
- W2913448064 cites W2343952032 @default.
- W2913448064 cites W2512436288 @default.
- W2913448064 cites W2512942811 @default.
- W2913448064 cites W2517590517 @default.
- W2913448064 cites W2529389767 @default.
- W2913448064 cites W2540989688 @default.
- W2913448064 cites W2555294103 @default.
- W2913448064 cites W2568758989 @default.
- W2913448064 cites W2570140560 @default.
- W2913448064 cites W2570141807 @default.
- W2913448064 cites W2587863476 @default.
- W2913448064 cites W2620369605 @default.
- W2913448064 cites W2623888527 @default.
- W2913448064 cites W2740681317 @default.
- W2913448064 cites W2744362817 @default.
- W2913448064 cites W2772776690 @default.
- W2913448064 cites W2789052533 @default.
- W2913448064 cites W2794439438 @default.
- W2913448064 cites W2808209724 @default.
- W2913448064 cites W2884796151 @default.