FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913448436> ?p ?o ?g. }

• W2913448436 endingPage "837" @default.
• W2913448436 startingPage "826" @default.
• W2913448436 abstract "Plant sterols have proven a potent anti-proliferative and apoptosis inducing agent against several carcinomas including breast and prostate cancers. Jab1 has been reported to be involved in the progression of numerous carcinomas. However, antiproliferative effects of sterols against Jab1 in gall bladder cancer have not been explored yet.In the current study, we elucidated the mechanism of action of stigmasterol regarding apoptosis induction mediated via downregulation of Jab1 protein in human gall bladder cancer cells.In our study, we performed MTT and Trypan blue assay to assess the effect of stigmasterol on cell proliferation. In addition, RT-PCR and western blotting were performed to identify the effect of stigmasterol on Jab1 and p27 expression in human gall bladder cancer cells. We further performed cell cycle, Caspase-3, Hoechst and FITC-Annexin V analysis, to confirm the apoptosis induction in stigmasterol treated human gall bladder cancer cells.Our results clearly indicated that stigmasterol has up-regulated the p27 expression and down-regulated Jab1 gene. These modulations of genes might occur via mitochondrial apoptosis signaling pathway. Caspase-3 gets activated with the apoptotic induction. Increase in apoptotic cells and DNA were confirmed through annexin V staining, Hoechst staining, and cell cycle analysis.Thus, these results strongly suggest that stigmasterol has the potential to be considered as an anticancerous therapeutic agent against Jab1 in gall bladder cancer." @default.
• W2913448436 created "2019-02-21" @default.
• W2913448436 creator A5006521821 @default.
• W2913448436 creator A5007205261 @default.
• W2913448436 creator A5014569649 @default.
• W2913448436 creator A5042729357 @default.
• W2913448436 creator A5054982412 @default.
• W2913448436 creator A5055097541 @default.
• W2913448436 creator A5067712926 @default.
• W2913448436 creator A5091062559 @default.
• W2913448436 date "2019-09-03" @default.
• W2913448436 modified "2023-10-03" @default.
• W2913448436 title "Elucidation of the Chemopreventive Role of Stigmasterol Against Jab1 in Gall Bladder Carcinoma" @default.
• W2913448436 cites W1845459216 @default.
• W2913448436 cites W1930293314 @default.
• W2913448436 cites W1965694039 @default.
• W2913448436 cites W1972779889 @default.
• W2913448436 cites W1982166284 @default.
• W2913448436 cites W1997701398 @default.
• W2913448436 cites W2008117638 @default.
• W2913448436 cites W2021469456 @default.
• W2913448436 cites W2025055344 @default.
• W2913448436 cites W2046024621 @default.
• W2913448436 cites W2072700574 @default.
• W2913448436 cites W2080572933 @default.
• W2913448436 cites W2089663038 @default.
• W2913448436 cites W2102799140 @default.
• W2913448436 cites W2103176523 @default.
• W2913448436 cites W2140355798 @default.
• W2913448436 cites W2141091145 @default.
• W2913448436 cites W2147464247 @default.
• W2913448436 cites W2163396326 @default.
• W2913448436 cites W2166280494 @default.
• W2913448436 cites W2237327058 @default.
• W2913448436 cites W2327301075 @default.
• W2913448436 cites W2342566422 @default.
• W2913448436 cites W2401546034 @default.
• W2913448436 cites W2581841075 @default.
• W2913448436 cites W2584377378 @default.
• W2913448436 cites W2751204281 @default.
• W2913448436 cites W2767296210 @default.
• W2913448436 cites W2789723565 @default.
• W2913448436 doi "https://doi.org/10.2174/1871530319666190206124120" @default.
• W2913448436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30727937" @default.
• W2913448436 hasPublicationYear "2019" @default.
• W2913448436 type Work @default.
• W2913448436 sameAs 2913448436 @default.
• W2913448436 citedByCount "22" @default.
• W2913448436 countsByYear W29134484362020 @default.
• W2913448436 countsByYear W29134484362021 @default.
• W2913448436 countsByYear W29134484362022 @default.
• W2913448436 countsByYear W29134484362023 @default.
• W2913448436 crossrefType "journal-article" @default.
• W2913448436 hasAuthorship W2913448436A5006521821 @default.
• W2913448436 hasAuthorship W2913448436A5007205261 @default.
• W2913448436 hasAuthorship W2913448436A5014569649 @default.
• W2913448436 hasAuthorship W2913448436A5042729357 @default.
• W2913448436 hasAuthorship W2913448436A5054982412 @default.
• W2913448436 hasAuthorship W2913448436A5055097541 @default.
• W2913448436 hasAuthorship W2913448436A5067712926 @default.
• W2913448436 hasAuthorship W2913448436A5091062559 @default.
• W2913448436 hasConcept C153911025 @default.
• W2913448436 hasConcept C190283241 @default.
• W2913448436 hasConcept C2778016309 @default.
• W2913448436 hasConcept C29537977 @default.
• W2913448436 hasConcept C502942594 @default.
• W2913448436 hasConcept C54355233 @default.
• W2913448436 hasConcept C55493867 @default.
• W2913448436 hasConcept C62112901 @default.
• W2913448436 hasConcept C86803240 @default.
• W2913448436 hasConcept C88634738 @default.
• W2913448436 hasConceptScore W2913448436C153911025 @default.
• W2913448436 hasConceptScore W2913448436C190283241 @default.
• W2913448436 hasConceptScore W2913448436C2778016309 @default.
• W2913448436 hasConceptScore W2913448436C29537977 @default.
• W2913448436 hasConceptScore W2913448436C502942594 @default.
• W2913448436 hasConceptScore W2913448436C54355233 @default.
• W2913448436 hasConceptScore W2913448436C55493867 @default.
• W2913448436 hasConceptScore W2913448436C62112901 @default.
• W2913448436 hasConceptScore W2913448436C86803240 @default.
• W2913448436 hasConceptScore W2913448436C88634738 @default.
• W2913448436 hasFunder F4320320719 @default.
• W2913448436 hasIssue "6" @default.
• W2913448436 hasLocation W29134484361 @default.
• W2913448436 hasLocation W29134484362 @default.
• W2913448436 hasOpenAccess W2913448436 @default.
• W2913448436 hasPrimaryLocation W29134484361 @default.
• W2913448436 hasRelatedWork W2005760610 @default.
• W2913448436 hasRelatedWork W2350294409 @default.
• W2913448436 hasRelatedWork W2351136637 @default.
• W2913448436 hasRelatedWork W2361963140 @default.
• W2913448436 hasRelatedWork W2376744432 @default.
• W2913448436 hasRelatedWork W2382230817 @default.
• W2913448436 hasRelatedWork W2383726173 @default.
• W2913448436 hasRelatedWork W2394129978 @default.
• W2913448436 hasRelatedWork W3031159451 @default.
• W2913448436 hasRelatedWork W3031375613 @default.
• W2913448436 hasVolume "19" @default.

• next