Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913449079> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2913449079 abstract "Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. This needs to be confirmed or refuted in a larger trial, which may be a challenge with respect to recruitment, since there are currently three additional biologics available to prescribe. Trial registration Clinicaltrials.gov, NCT02049294, Registered 30th January 2014, https://clinicaltrials.gov/ct2/show/NCT02049294" @default.
- W2913449079 created "2019-02-21" @default.
- W2913449079 creator A5022260354 @default.
- W2913449079 creator A5029497606 @default.
- W2913449079 creator A5034326725 @default.
- W2913449079 creator A5038119081 @default.
- W2913449079 creator A5041406254 @default.
- W2913449079 creator A5048737172 @default.
- W2913449079 creator A5058199788 @default.
- W2913449079 creator A5075416098 @default.
- W2913449079 creator A5080761198 @default.
- W2913449079 creator A5087705837 @default.
- W2913449079 creator A5091305347 @default.
- W2913449079 date "2019-02-01" @default.
- W2913449079 modified "2023-10-16" @default.
- W2913449079 title "Omalizumab in Patients with Severe Asthma and Persistent Sputum Eosinophilia" @default.
- W2913449079 doi "https://doi.org/10.1016/j.jaci.2018.12.984" @default.
- W2913449079 hasPublicationYear "2019" @default.
- W2913449079 type Work @default.
- W2913449079 sameAs 2913449079 @default.
- W2913449079 citedByCount "0" @default.
- W2913449079 crossrefType "journal-article" @default.
- W2913449079 hasAuthorship W2913449079A5022260354 @default.
- W2913449079 hasAuthorship W2913449079A5029497606 @default.
- W2913449079 hasAuthorship W2913449079A5034326725 @default.
- W2913449079 hasAuthorship W2913449079A5038119081 @default.
- W2913449079 hasAuthorship W2913449079A5041406254 @default.
- W2913449079 hasAuthorship W2913449079A5048737172 @default.
- W2913449079 hasAuthorship W2913449079A5058199788 @default.
- W2913449079 hasAuthorship W2913449079A5075416098 @default.
- W2913449079 hasAuthorship W2913449079A5080761198 @default.
- W2913449079 hasAuthorship W2913449079A5087705837 @default.
- W2913449079 hasAuthorship W2913449079A5091305347 @default.
- W2913449079 hasBestOaLocation W29134490791 @default.
- W2913449079 hasConcept C126322002 @default.
- W2913449079 hasConcept C141105273 @default.
- W2913449079 hasConcept C142724271 @default.
- W2913449079 hasConcept C159654299 @default.
- W2913449079 hasConcept C168563851 @default.
- W2913449079 hasConcept C177713679 @default.
- W2913449079 hasConcept C187212893 @default.
- W2913449079 hasConcept C203014093 @default.
- W2913449079 hasConcept C204787440 @default.
- W2913449079 hasConcept C27081682 @default.
- W2913449079 hasConcept C2776042228 @default.
- W2913449079 hasConcept C2776301714 @default.
- W2913449079 hasConcept C2776804153 @default.
- W2913449079 hasConcept C2777129736 @default.
- W2913449079 hasConcept C2778564945 @default.
- W2913449079 hasConcept C2781069245 @default.
- W2913449079 hasConcept C71924100 @default.
- W2913449079 hasConceptScore W2913449079C126322002 @default.
- W2913449079 hasConceptScore W2913449079C141105273 @default.
- W2913449079 hasConceptScore W2913449079C142724271 @default.
- W2913449079 hasConceptScore W2913449079C159654299 @default.
- W2913449079 hasConceptScore W2913449079C168563851 @default.
- W2913449079 hasConceptScore W2913449079C177713679 @default.
- W2913449079 hasConceptScore W2913449079C187212893 @default.
- W2913449079 hasConceptScore W2913449079C203014093 @default.
- W2913449079 hasConceptScore W2913449079C204787440 @default.
- W2913449079 hasConceptScore W2913449079C27081682 @default.
- W2913449079 hasConceptScore W2913449079C2776042228 @default.
- W2913449079 hasConceptScore W2913449079C2776301714 @default.
- W2913449079 hasConceptScore W2913449079C2776804153 @default.
- W2913449079 hasConceptScore W2913449079C2777129736 @default.
- W2913449079 hasConceptScore W2913449079C2778564945 @default.
- W2913449079 hasConceptScore W2913449079C2781069245 @default.
- W2913449079 hasConceptScore W2913449079C71924100 @default.
- W2913449079 hasLocation W29134490791 @default.
- W2913449079 hasLocation W29134490792 @default.
- W2913449079 hasLocation W29134490793 @default.
- W2913449079 hasOpenAccess W2913449079 @default.
- W2913449079 hasPrimaryLocation W29134490791 @default.
- W2913449079 hasRelatedWork W12465354 @default.
- W2913449079 hasRelatedWork W14982225 @default.
- W2913449079 hasRelatedWork W15216135 @default.
- W2913449079 hasRelatedWork W15483090 @default.
- W2913449079 hasRelatedWork W17641196 @default.
- W2913449079 hasRelatedWork W18018281 @default.
- W2913449079 hasRelatedWork W4217252 @default.
- W2913449079 hasRelatedWork W5187374 @default.
- W2913449079 hasRelatedWork W8981580 @default.
- W2913449079 hasRelatedWork W9655381 @default.
- W2913449079 isParatext "false" @default.
- W2913449079 isRetracted "false" @default.
- W2913449079 magId "2913449079" @default.
- W2913449079 workType "article" @default.