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• W2913458859 abstract "Temperature has unequivocal effects on several aspects of fish physiology, but the full extent of its interaction with key endocrine signaling systems to influence metabolic function remains unknown. The aim of the current study was to assess the individual and combined effects of elevated temperature and hyperthyroidism on hepatic metabolism in juvenile lake whitefish by quantifying mRNA abundance and activity of key metabolic enzymes. Fish were exposed to 13 (control), 17 or 21 °C for 0, 4, 8 or 24 days in the presence or absence of low-T4 (1 µg × g body weight−1) or high-T4 (10 µg × g body weight−1) treatment. Our results demonstrate moderate sensitivity to elevated temperature in this species, characterized by short-term changes in mRNA abundance of several metabolic enzymes and long-term declines in citrate synthase (CS) and cytochrome c oxidase (COX) activities. T4-induced hyperthyroidism also had several short-term effects on mRNA abundance of metabolic transcripts, including depressions in acetyl-coA carboxylase β (accβ) and carnitine palmitoyltransferase 1β (cpt1β), and stabilization of cs mRNA levels; however, these effects were primarily limited to elevated temperature groups, indicating temperature-dependent effects of exogenous T4 treatment in this species. In contrast, maximal CS and COX activities were not altered by hyperthyroidism at any temperature. Collectively, our data suggest that temperature has the potential to manipulate thyroid hormone physiology in juvenile lake whitefish and, under warm-conditions, hyperthyroidism may suppress certain elements of the β-oxidation pathway without substantial impacts on overall cellular oxidative capacity." @default.
• W2913458859 created "2019-02-21" @default.
• W2913458859 creator A5030168218 @default.
• W2913458859 creator A5054636953 @default.
• W2913458859 date "2019-05-01" @default.
• W2913458859 modified "2023-09-27" @default.
• W2913458859 title "Expression and activity of lipid and oxidative metabolism enzymes following elevated temperature exposure and thyroid hormone manipulation in juvenile lake whitefish (Coregonus clupeaformis)" @default.
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• W2913458859 doi "https://doi.org/10.1016/j.ygcen.2019.02.001" @default.
• W2913458859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721659" @default.
• W2913458859 hasPublicationYear "2019" @default.
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