Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913459787> ?p ?o ?g. }
- W2913459787 endingPage "e168" @default.
- W2913459787 startingPage "e168" @default.
- W2913459787 abstract "Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that exist at very low numbers in healthy subjects but can expand significantly in malignant, infectious, and chronic inflammatory diseases. These cells are characterized as early-MDSCs, monocytic-MDSCs, and polymorphonuclear-MDSCs and can be studied on the basis of their immunophenotypic characteristics and their functional properties to suppress T-cell activation and proliferation. MDSCs have emerged as important contributors to tumor expansion and chronic inflammation progression by inducing immunosuppressive mechanisms, angiogenesis and drug resistance. Most experimental and clinical studies concerning MDSCs have been mainly focused on solid tumors. In recent years, however, the implication of MDSCs in the immune dysregulation associated with hematologic malignancies, immune-mediated cytopenias and allogeneic hemopoietic stem cell transplantation has been documented and the potential role of these cells as biomarkers and therapeutic targets has started to attract a particular interest in hematology. The elucidation of the molecular and signaling pathways associated with the generation, expansion and function of MDSCs in malignant and immune-mediated hematologic diseases and the clarification of mechanisms related to the circulation and the crosstalk of MDSCs with malignant cells and other components of the immune system are anticipated to lead to novel therapeutic strategies. This review summarizes all available evidence on the implication of MDSCs in hematologic diseases highlighting the challenges and perspectives arising from this novel field of research." @default.
- W2913459787 created "2019-02-21" @default.
- W2913459787 creator A5014727099 @default.
- W2913459787 creator A5044571137 @default.
- W2913459787 creator A5048068750 @default.
- W2913459787 creator A5048870451 @default.
- W2913459787 creator A5053917995 @default.
- W2913459787 creator A5061874493 @default.
- W2913459787 creator A5066883045 @default.
- W2913459787 creator A5068540445 @default.
- W2913459787 creator A5073641524 @default.
- W2913459787 creator A5078913930 @default.
- W2913459787 creator A5090272429 @default.
- W2913459787 date "2019-02-01" @default.
- W2913459787 modified "2023-10-04" @default.
- W2913459787 title "Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets" @default.
- W2913459787 cites W1260486040 @default.
- W2913459787 cites W1552120844 @default.
- W2913459787 cites W1567450894 @default.
- W2913459787 cites W1832098911 @default.
- W2913459787 cites W1859880942 @default.
- W2913459787 cites W1877245175 @default.
- W2913459787 cites W1925817305 @default.
- W2913459787 cites W1954731853 @default.
- W2913459787 cites W1970436433 @default.
- W2913459787 cites W1971812559 @default.
- W2913459787 cites W1987344839 @default.
- W2913459787 cites W1990381878 @default.
- W2913459787 cites W1995232616 @default.
- W2913459787 cites W1999450011 @default.
- W2913459787 cites W2004150448 @default.
- W2913459787 cites W2004445332 @default.
- W2913459787 cites W2008658155 @default.
- W2913459787 cites W2008717037 @default.
- W2913459787 cites W2013575415 @default.
- W2913459787 cites W2015919529 @default.
- W2913459787 cites W2018555744 @default.
- W2913459787 cites W2022380404 @default.
- W2913459787 cites W2022505130 @default.
- W2913459787 cites W2031626045 @default.
- W2913459787 cites W2034812478 @default.
- W2913459787 cites W2035110681 @default.
- W2913459787 cites W2037118053 @default.
- W2913459787 cites W2037338605 @default.
- W2913459787 cites W2040986265 @default.
- W2913459787 cites W2052605694 @default.
- W2913459787 cites W2054554805 @default.
- W2913459787 cites W2061217549 @default.
- W2913459787 cites W2062873927 @default.
- W2913459787 cites W2071113689 @default.
- W2913459787 cites W2078021593 @default.
- W2913459787 cites W2081498322 @default.
- W2913459787 cites W2084015186 @default.
- W2913459787 cites W2088827979 @default.
- W2913459787 cites W2093381200 @default.
- W2913459787 cites W2095868502 @default.
- W2913459787 cites W2099402024 @default.
- W2913459787 cites W2101996346 @default.
- W2913459787 cites W2105565011 @default.
- W2913459787 cites W2105758141 @default.
- W2913459787 cites W2111063688 @default.
- W2913459787 cites W2120539661 @default.
- W2913459787 cites W2122403898 @default.
- W2913459787 cites W2126431419 @default.
- W2913459787 cites W2126503106 @default.
- W2913459787 cites W2138208694 @default.
- W2913459787 cites W2142851096 @default.
- W2913459787 cites W2143473356 @default.
- W2913459787 cites W2144186438 @default.
- W2913459787 cites W2153436924 @default.
- W2913459787 cites W2159290059 @default.
- W2913459787 cites W2178963310 @default.
- W2913459787 cites W2230702682 @default.
- W2913459787 cites W2284541528 @default.
- W2913459787 cites W2295129153 @default.
- W2913459787 cites W2307271768 @default.
- W2913459787 cites W2325356223 @default.
- W2913459787 cites W2326735612 @default.
- W2913459787 cites W2336509969 @default.
- W2913459787 cites W2339658711 @default.
- W2913459787 cites W2340797329 @default.
- W2913459787 cites W2343744011 @default.
- W2913459787 cites W2354382776 @default.
- W2913459787 cites W2400276917 @default.
- W2913459787 cites W2468972176 @default.
- W2913459787 cites W2470898142 @default.
- W2913459787 cites W2470979010 @default.
- W2913459787 cites W2471500324 @default.
- W2913459787 cites W2476386652 @default.
- W2913459787 cites W2488076079 @default.
- W2913459787 cites W2497459119 @default.
- W2913459787 cites W2519770732 @default.
- W2913459787 cites W2527549654 @default.
- W2913459787 cites W2564723173 @default.
- W2913459787 cites W2568946517 @default.
- W2913459787 cites W2577785715 @default.
- W2913459787 cites W2580571122 @default.
- W2913459787 cites W2585558237 @default.