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- W2913461215 abstract "Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). While the administration of L-dopa and deep brain stimulation are potent therapies, their costs, side effects and gradual loss of efficacy underlines the need to develop other approaches. Unfortunately, the lack of pertinent animal models that reproduce DA neuron loss and behaviour deficits - in a timeline that mimics PD progression - has hindered the identification of alternative therapies. A complementary approach to transgenic animals is the use of nonhuman primates combined with the overexpression of disease-related genes using viral vectors. This approach may induce phenotypes that are not influenced by developmental compensation mechanisms, and that take into account the personality of animals. In this review, we discuss the combination of gene transfer and nonhuman primate to develop “genetic” models of PD that are suitable for testing therapeutic approaches." @default.
- W2913461215 created "2019-02-21" @default.
- W2913461215 creator A5011865615 @default.
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- W2913461215 creator A5058497920 @default.
- W2913461215 creator A5066721468 @default.
- W2913461215 creator A5075186690 @default.
- W2913461215 date "2019-02-11" @default.
- W2913461215 modified "2023-10-07" @default.
- W2913461215 title "Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson’s Disease" @default.
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