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• W2913461427 abstract "Abstract Aim Vitamin D 3 or 25(OH)D 3 may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro‐inflammatory cytokines including interleukin‐6 (IL‐6). The aim of this study is to determine the clinical factors of vitamin D deficiency in multi‐ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL‐6 levels. Method One hundred RA patients and 50 healthy controls, sex‐ and age‐matched, were recruited. Disease Activity Score of 28 joints and Health Assessment Questionnaire scores were assessed. Baseline serum 25(OH)D 3 and IL‐6 were measured in all subjects. RA patients who were vitamin D deficient were given loading doses of vitamin D 3 and repeated assessments were done. Results Vitamin D deficiency (<50 nmol/L) was found in 63% of RA patients and 76% of healthy controls. Chinese RA patients and healthy controls had significantly more sufficient 25(OH)D 3 levels compared to Malays and Indians ( P < 0.001). Serum 25(OH)D 3 level was still negatively associated with body mass index in RA patients ( P = 0.002) after adjustment for potential confounding variables. No significant association was seen between 25(OH)D 3 levels and disease activity or serum IL‐6 levels in both pre‐ and post‐treatment groups. A negative association was observed between serum 25(OH)D 3 and functional disability, including a 33% improvement post‐treatment (mean ± SD: 0.30 ± 0.46 to 0.20 ± 0.18). Conclusion Vitamin D deficiency is prevalent in Malaysian RA patients. This study suggests that vitamin D is not associated with disease activity or serum IL‐6 levels but it may have a role in functional disability in RA patients." @default.
• W2913461427 created "2019-02-21" @default.
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• W2913461427 date "2019-02-06" @default.
• W2913461427 modified "2023-10-01" @default.
• W2913461427 title "Effects of vitamin D on disease activity and serum interleukin‐6 in rheumatoid arthritis" @default.
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• W2913461427 doi "https://doi.org/10.1111/1756-185x.13484" @default.
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