FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913475964> ?p ?o ?g. }

• W2913475964 endingPage "51" @default.
• W2913475964 startingPage "42" @default.
• W2913475964 abstract "An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impaired behavior, and somatic symptoms, women with TBI report amenorrhea or irregular menstrual cycles suggestive of disruptions in the hypothalamic-pituitary-gonadal (HPG) axis. HPG dysfunction following TBI has been linked to poor functional outcome in men and women, but the mechanisms by which this may occur or relate to behavior has not been fully developed or ascertained. The present study determined if TBI resulted in HPG axis perturbations in young adult female Sprague Dawley rats, and whether TBI was associated with cognitive and sensorimotor deficits. Following lateral fluid percussion injury, injured females spent significantly more time in diestrus compared to sham females, consistent with a persistent low sex-steroid hormone state. Injured females displayed significantly reduced 17β-estradiol (E2) and luteinizing hormone levels. Concomitantly, injured females were impaired in spatial working memory compared to shams. Impaired GSK3β/β-catenin signaling related to synaptic changes was evident one-week post-injury in the hippocampus among injured females compared to sham females, and this impairment paralleled the deficits in spatial working memory. Sensorimotor function, as evidenced by suppression of the acoustic startle response, was chronically impaired even after normal estrous cycling resumed. These data demonstrate that TBI results in estrous cycle impairments, memory dysfunction, and perturbations in GSK3β/β-catenin signaling, suggesting a potential mechanism for HPG-mediated cognitive impairment following TBI." @default.
• W2913475964 created "2019-02-21" @default.
• W2913475964 creator A5013561770 @default.
• W2913475964 creator A5035950340 @default.
• W2913475964 creator A5058940794 @default.
• W2913475964 creator A5072853922 @default.
• W2913475964 creator A5087935572 @default.
• W2913475964 date "2019-05-01" @default.
• W2913475964 modified "2023-10-18" @default.
• W2913475964 title "Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats" @default.
• W2913475964 cites W1603850560 @default.
• W2913475964 cites W1836073406 @default.
• W2913475964 cites W1838129259 @default.
• W2913475964 cites W1970991292 @default.
• W2913475964 cites W1971124182 @default.
• W2913475964 cites W1978663099 @default.
• W2913475964 cites W1978714931 @default.
• W2913475964 cites W1983794138 @default.
• W2913475964 cites W1986133498 @default.
• W2913475964 cites W1992605879 @default.
• W2913475964 cites W1996125219 @default.
• W2913475964 cites W2002090514 @default.
• W2913475964 cites W2005139532 @default.
• W2913475964 cites W2014228446 @default.
• W2913475964 cites W2025840069 @default.
• W2913475964 cites W2030158939 @default.
• W2913475964 cites W2034354239 @default.
• W2913475964 cites W2034627732 @default.
• W2913475964 cites W2034679108 @default.
• W2913475964 cites W2035277900 @default.
• W2913475964 cites W2037486805 @default.
• W2913475964 cites W2038715873 @default.
• W2913475964 cites W2045301301 @default.
• W2913475964 cites W2048627963 @default.
• W2913475964 cites W2051733099 @default.
• W2913475964 cites W2057313063 @default.
• W2913475964 cites W2057742222 @default.
• W2913475964 cites W2059289119 @default.
• W2913475964 cites W2059928135 @default.
• W2913475964 cites W2066386698 @default.
• W2913475964 cites W2067003329 @default.
• W2913475964 cites W2067131324 @default.
• W2913475964 cites W2067156695 @default.
• W2913475964 cites W2070221838 @default.
• W2913475964 cites W2072974386 @default.
• W2913475964 cites W2073436852 @default.
• W2913475964 cites W2090316207 @default.
• W2913475964 cites W2093170219 @default.
• W2913475964 cites W2096022216 @default.
• W2913475964 cites W2099180554 @default.
• W2913475964 cites W2099702361 @default.
• W2913475964 cites W2101301851 @default.
• W2913475964 cites W2116462752 @default.
• W2913475964 cites W2119691301 @default.
• W2913475964 cites W2126384423 @default.
• W2913475964 cites W2129780974 @default.
• W2913475964 cites W2146599264 @default.
• W2913475964 cites W2165659494 @default.
• W2913475964 cites W2166531273 @default.
• W2913475964 cites W2198784994 @default.
• W2913475964 cites W2215469304 @default.
• W2913475964 cites W2275430691 @default.
• W2913475964 cites W2293042522 @default.
• W2913475964 cites W2297073387 @default.
• W2913475964 cites W2301996563 @default.
• W2913475964 cites W2305039486 @default.
• W2913475964 cites W2307390251 @default.
• W2913475964 cites W2309480232 @default.
• W2913475964 cites W2316369254 @default.
• W2913475964 cites W2337518024 @default.
• W2913475964 cites W2514451738 @default.
• W2913475964 cites W2571335019 @default.
• W2913475964 cites W2737058806 @default.
• W2913475964 cites W2777832450 @default.
• W2913475964 cites W2795436594 @default.
• W2913475964 cites W2801231655 @default.
• W2913475964 cites W2804503506 @default.
• W2913475964 cites W2811350671 @default.
• W2913475964 cites W4244331337 @default.
• W2913475964 cites W4381156879 @default.
• W2913475964 doi "https://doi.org/10.1016/j.expneurol.2019.01.017" @default.
• W2913475964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30710530" @default.
• W2913475964 hasPublicationYear "2019" @default.
• W2913475964 type Work @default.
• W2913475964 sameAs 2913475964 @default.
• W2913475964 citedByCount "18" @default.
• W2913475964 countsByYear W29134759642019 @default.
• W2913475964 countsByYear W29134759642020 @default.
• W2913475964 countsByYear W29134759642021 @default.
• W2913475964 countsByYear W29134759642023 @default.
• W2913475964 crossrefType "journal-article" @default.
• W2913475964 hasAuthorship W2913475964A5013561770 @default.
• W2913475964 hasAuthorship W2913475964A5035950340 @default.
• W2913475964 hasAuthorship W2913475964A5058940794 @default.
• W2913475964 hasAuthorship W2913475964A5072853922 @default.
• W2913475964 hasAuthorship W2913475964A5087935572 @default.
• W2913475964 hasConcept C118552586 @default.
• W2913475964 hasConcept C126322002 @default.

• next