Matches in SemOpenAlex for { <https://semopenalex.org/work/W291350300> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- W291350300 endingPage "357" @default.
- W291350300 startingPage "354" @default.
- W291350300 abstract "目的观察雌激素对大鼠局灶性脑缺血再灌注损伤后核转录因子-κB（NF-κB）和肿瘤坏死因子（TNF-α）表达的影响,探讨雌激素对大鼠局灶性脑缺血再灌注损伤的神经保护机制。方法49只雌性Wistar大鼠随机分为4组：脑缺血再灌注组（A组）、卵巢切除组（B组）、雌激素给药组（C组）、假手术组（D组）,A、B、C组每组14只,假手术组7只。除假手术组外其余大鼠均采用大脑中动脉线栓法建立局灶性脑缺血再灌注模型,采用免疫组织化学方法检测脑组织NF-κB和TNF-α的表达,HE染色显微镜下观察脑组织病理学变化。结果HE染色：B组与A组和C组比较,脑组织损害较重;免疫组织化学检测：B组NF-κB和TNF-α表达的阳性细胞率在同一时间点明显高于A组及C组（P〈0.05）,各组不同时间点NF-κB和TNF-α表达的阳性细胞率不同,随时间的延长表达增强（P〈0.05）。结论雌激素能抑制脑缺血再灌注损伤后炎症反应,减轻切除卵巢大鼠局灶性脑缺血引起的脑损伤,具有缺血性神经保护作用。" @default.
- W291350300 created "2016-06-24" @default.
- W291350300 creator A5041976867 @default.
- W291350300 creator A5066954311 @default.
- W291350300 creator A5076765331 @default.
- W291350300 date "2008-01-01" @default.
- W291350300 modified "2023-09-23" @default.
- W291350300 title "7β-雌二醇对大鼠局灶性脑缺血再灌注损伤后NF-κB及TNF-α表达的影响" @default.
- W291350300 hasPublicationYear "2008" @default.
- W291350300 type Work @default.
- W291350300 sameAs 291350300 @default.
- W291350300 citedByCount "0" @default.
- W291350300 crossrefType "journal-article" @default.
- W291350300 hasAuthorship W291350300A5041976867 @default.
- W291350300 hasAuthorship W291350300A5066954311 @default.
- W291350300 hasAuthorship W291350300A5076765331 @default.
- W291350300 hasConcept C17991360 @default.
- W291350300 hasConcept C203014093 @default.
- W291350300 hasConcept C86803240 @default.
- W291350300 hasConceptScore W291350300C17991360 @default.
- W291350300 hasConceptScore W291350300C203014093 @default.
- W291350300 hasConceptScore W291350300C86803240 @default.
- W291350300 hasIssue "4" @default.
- W291350300 hasLocation W2913503001 @default.
- W291350300 hasOpenAccess W291350300 @default.
- W291350300 hasPrimaryLocation W2913503001 @default.
- W291350300 hasVolume "42" @default.
- W291350300 isParatext "false" @default.
- W291350300 isRetracted "false" @default.
- W291350300 magId "291350300" @default.
- W291350300 workType "article" @default.