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- W2913542955 abstract "Vasoactive intestinal peptide (VIP) is a neuropeptide that is widely distributed in the central and peripheral nervous systems. VIP and its receptors are expressed in practically all pulmonary structures, including airway epithelial cells, airway and pulmonary vascular smooth muscle, secretory glands, and immune and inflammatory cells. VIP actions in the lung include the relaxation of airway and vascular smooth muscle and inhibition of their proliferation, modulation of inflammatory and immune responses, and protection against acute injury. Strong evidence, recently supported by findings in VIP knockout mice, suggests that VIP has important physiological roles in the transmission of airway and pulmonary vascular smooth muscle relaxation, the modulation of immune and inflammatory responses, and the defense of the lung against bronchial asthma and acute injury. VIP therefore is of potential therapeutic benefit in bronchial asthma, pulmonary hypertension, acute lung injury, the acute respiratory distress syndrome, and the multiorgan failure syndrome." @default.
- W2913542955 created "2019-02-21" @default.
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- W2913542955 date "2006-01-01" @default.
- W2913542955 modified "2023-09-26" @default.
- W2913542955 title "Vasoactive Intestinal Peptide" @default.
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- W2913542955 doi "https://doi.org/10.1016/b978-012369442-3/50184-7" @default.
- W2913542955 hasPublicationYear "2006" @default.
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