Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913550068> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2913550068 endingPage "S718" @default.
- W2913550068 startingPage "S718" @default.
- W2913550068 abstract "Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is difficult. Multifocal pancreatic masses are not common when it comes to PDAC. This especially holds true for cancer of the pancreatic body and tail that do not manifest with jaundice. We present a case of pancreatic cancer involving the head and tail A 52-year-old Caucasian male with past history of hypertension, gout and osteoarthritis presented to the hospital with acute left upper quadrant pain radiating to the back after sustaining a fall. Examination revealed severe tenderness to palpation of the left upper quadrant. Initial laboratory data showed hemoglobin of 10.4 g/dl, AST of 166 U/L, ALT of 352 U/L, ALP of 368 U/L and serum lipase level of 869 U/L. CT abdomen showed splenic laceration with hemoperitoneum. The patient was vigorously resuscitated, and subsequently underwent emergency laparotomy. Operative findings revealed splenic laceration with hemoperitoneum. Intraoperatively, the pancreatic tail was hard and abutted the mesocolon and omentum. Short gastric vessels were engorged suggestive of splenic vein thrombosis. Irregular masses were noticed in the head of the pancreas without involvement of superior mesenteric vasculature. Histopathology of the mass revealed PDAC. The patient underwent Whipple surgery with adjuvant FOLFIRINOX therapy. Post-operative pathology showed T3N1 disease with perineural and lymphovascular invasion. The patient is currently undergoing surveillance for recurrence. Splenic rupture is extremely rare presenting feature of pancreatic cancer. Only ten prior cases have been reported in literature. Most of those cases reported rupture of splenic artery aneurysm secondary to direct vascular invasion of PDAC. Cancer of the pancreatic tail can invade the splenic hilum causing splenic ischemia and vein occlusion which may culminate in splenic rupture. Another rare finding in our case was the multifocal nature of pancreatic cancer. Only around 50 cases have been reported so far as per our literature review. Most of the cases that have been reported in literature present as contiguous masses. Surgical removal is recommended in the absence of distant metastatic disease and local vascular invasion. Overall prognosis continues to remain grim for all stages.Figure: Splenic rupture is a rare presenting feature of pancreatic cancer. It can however present an opportunity for early stage discovery that may lead to improvement in prognosis by earlier initiation of treatment." @default.
- W2913550068 created "2019-02-21" @default.
- W2913550068 creator A5014286609 @default.
- W2913550068 creator A5028396779 @default.
- W2913550068 creator A5077563079 @default.
- W2913550068 creator A5080613674 @default.
- W2913550068 creator A5083136010 @default.
- W2913550068 date "2017-10-01" @default.
- W2913550068 modified "2023-10-18" @default.
- W2913550068 title "Fortuitous Splenic Rupture: An Unusual Presentation of Pancreatic Cancer" @default.
- W2913550068 doi "https://doi.org/10.14309/00000434-201710001-01321" @default.
- W2913550068 hasPublicationYear "2017" @default.
- W2913550068 type Work @default.
- W2913550068 sameAs 2913550068 @default.
- W2913550068 citedByCount "0" @default.
- W2913550068 crossrefType "journal-article" @default.
- W2913550068 hasAuthorship W2913550068A5014286609 @default.
- W2913550068 hasAuthorship W2913550068A5028396779 @default.
- W2913550068 hasAuthorship W2913550068A5077563079 @default.
- W2913550068 hasAuthorship W2913550068A5080613674 @default.
- W2913550068 hasAuthorship W2913550068A5083136010 @default.
- W2913550068 hasConcept C121608353 @default.
- W2913550068 hasConcept C126322002 @default.
- W2913550068 hasConcept C126838900 @default.
- W2913550068 hasConcept C141071460 @default.
- W2913550068 hasConcept C142724271 @default.
- W2913550068 hasConcept C2775967933 @default.
- W2913550068 hasConcept C2776309230 @default.
- W2913550068 hasConcept C2776670229 @default.
- W2913550068 hasConcept C2776981413 @default.
- W2913550068 hasConcept C2777214474 @default.
- W2913550068 hasConcept C2778259530 @default.
- W2913550068 hasConcept C2778764654 @default.
- W2913550068 hasConcept C2778808290 @default.
- W2913550068 hasConcept C2780210213 @default.
- W2913550068 hasConcept C2780333324 @default.
- W2913550068 hasConcept C2780931953 @default.
- W2913550068 hasConcept C544855455 @default.
- W2913550068 hasConcept C71924100 @default.
- W2913550068 hasConcept C90924648 @default.
- W2913550068 hasConceptScore W2913550068C121608353 @default.
- W2913550068 hasConceptScore W2913550068C126322002 @default.
- W2913550068 hasConceptScore W2913550068C126838900 @default.
- W2913550068 hasConceptScore W2913550068C141071460 @default.
- W2913550068 hasConceptScore W2913550068C142724271 @default.
- W2913550068 hasConceptScore W2913550068C2775967933 @default.
- W2913550068 hasConceptScore W2913550068C2776309230 @default.
- W2913550068 hasConceptScore W2913550068C2776670229 @default.
- W2913550068 hasConceptScore W2913550068C2776981413 @default.
- W2913550068 hasConceptScore W2913550068C2777214474 @default.
- W2913550068 hasConceptScore W2913550068C2778259530 @default.
- W2913550068 hasConceptScore W2913550068C2778764654 @default.
- W2913550068 hasConceptScore W2913550068C2778808290 @default.
- W2913550068 hasConceptScore W2913550068C2780210213 @default.
- W2913550068 hasConceptScore W2913550068C2780333324 @default.
- W2913550068 hasConceptScore W2913550068C2780931953 @default.
- W2913550068 hasConceptScore W2913550068C544855455 @default.
- W2913550068 hasConceptScore W2913550068C71924100 @default.
- W2913550068 hasConceptScore W2913550068C90924648 @default.
- W2913550068 hasLocation W29135500681 @default.
- W2913550068 hasOpenAccess W2913550068 @default.
- W2913550068 hasPrimaryLocation W29135500681 @default.
- W2913550068 hasRelatedWork W2045187061 @default.
- W2913550068 hasRelatedWork W2114535970 @default.
- W2913550068 hasRelatedWork W2159305792 @default.
- W2913550068 hasRelatedWork W2349477376 @default.
- W2913550068 hasRelatedWork W2400500812 @default.
- W2913550068 hasRelatedWork W2417485690 @default.
- W2913550068 hasRelatedWork W2465588918 @default.
- W2913550068 hasRelatedWork W2617206005 @default.
- W2913550068 hasRelatedWork W3094547668 @default.
- W2913550068 hasRelatedWork W97382052 @default.
- W2913550068 hasVolume "112" @default.
- W2913550068 isParatext "false" @default.
- W2913550068 isRetracted "false" @default.
- W2913550068 magId "2913550068" @default.
- W2913550068 workType "article" @default.