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- W2913591273 abstract "Negative blood oxygenation–level dependent (BOLD) signal observed during task execution in functional magnetic resonance imaging (fMRI) can be caused by different mechanisms, such as a blood-stealing effect or neuronal deactivation. Electrophysiological recordings showed that neuronal deactivation underlies the negative BOLD observed in the occipital lobe during visual stimulation. In this study, the metabolic demand of such a response was studied by measuring local metabolite concentration changes during a visual checkerboard stimulation using functional magnetic resonance spectroscopy (fMRS) at 7 Tesla. The results showed increases of glutamate and lactate concentrations during the positive BOLD response, consistent with previous fMRS studies. In contrast, during the negative BOLD response, decreasing concentrations of glutamate, lactate and gamma-aminobutyric acid (GABA) were found, suggesting a reduction of glycolytic and oxidative metabolic demand below the baseline. Additionally, the respective changes of the BOLD signal, glutamate and lactate concentrations of both groups suggest that a local increase of inhibitory activity might occur during the negative BOLD response." @default.
- W2913591273 created "2019-02-21" @default.
- W2913591273 creator A5015434390 @default.
- W2913591273 creator A5023023068 @default.
- W2913591273 creator A5029409294 @default.
- W2913591273 creator A5073620993 @default.
- W2913591273 date "2019-02-12" @default.
- W2913591273 modified "2023-10-18" @default.
- W2913591273 title "Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla" @default.
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- W2913591273 doi "https://doi.org/10.1177/0271678x19831022" @default.
- W2913591273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7026843" @default.
- W2913591273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755134" @default.
- W2913591273 hasPublicationYear "2019" @default.
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