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• W2913592513 abstract "Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic inflammation has also been related to oxidative stress. Palmitic acid ( PA ) is the most abundant free fatty acid found in food, and in vitro studies indicate that it triggers a pro‐inflammatory response in the brain. Melanocortins are neuropeptides with proven anti‐inflammatory and neuroprotective action mediated by melanocortin receptor 4 ( MC 4R), but little is known about the effect of melanocortins on oxidative stress. The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet ( HFD ) model. We found that NDP ‐ MSH treatment decreased PA ‐induced reactive oxygen species production in astrocytes, an effect blocked by the MC 4R inhibitor JKC 363. NDP ‐ MSH abolished nuclear translocation of Nrf2 induced by PA and blocked the inhibitory effect of PA on superoxide dismutase ( SOD ) activity and glutathione levels while it also per se increased activity of SOD and γ‐glutamate cysteine ligase (γ‐ GCL ) antioxidant enzymes. However, HFD reduced hypothalamic MC 4R and brain derived neurotrophic factor mRNA levels, thereby preventing the neuroprotective mechanism induced by melanocortins." @default.
• W2913592513 created "2019-02-21" @default.
• W2913592513 creator A5002999200 @default.
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• W2913592513 date "2019-02-01" @default.
• W2913592513 modified "2023-10-17" @default.
• W2913592513 title "NDP‐MSH reduces oxidative damage induced by palmitic acid in primary astrocytes" @default.
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• W2913592513 doi "https://doi.org/10.1111/jne.12673" @default.
• W2913592513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30712280" @default.
• W2913592513 hasPublicationYear "2019" @default.
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