FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913596162> ?p ?o ?g. }

• W2913596162 abstract "The reduced risk of colorectal cancer associated with cyclooxygenase enzyme inhibitors, such as aspirin and other nonsteroidal anti-inflammatory drugs, strongly suggests that chronic inflammation is a key mediator in the development of colorectal cancer. This complements recent molecular evidence demonstrating an association between a number of proinflammatory genetic polymorphisms and risk of colorectal cancer. We assessed polymorphisms in the IL-1, IL-10, TNF-A, and TGF-B genes in a populationbased case-control study of colorectal cancer cases (n = 264) and frequency-matched controls (n = 408) in the Northeast of Scotland and analyzed their interaction with regular aspirin use. There was no evidence of a relation between any of the individual polymorphisms, or pairs of polymorphisms, and risk of colorectal cancer. There was a significant interaction between the IL-10-592 C/A polymorphism and aspirin use (P interaction = 0.03). Carriers of the variant IL-10-592 (A) allele, who produce less of the antiinflammatory cytokine interleukin-10, had a statistically significant 50% reduced risk of colorectal cancer when taking regular aspirin (odds ratio, 0.5; 95% confidence interval, 0.25-0.97), whereas risk was not reduced in carriers of the A allele who did not use aspirin, or among aspirin users with the CC genotype. It is possible that carriers of the mutant IL-10-592 allele are more likely to derive antiinflammatory and chemopreventive benefits from aspirin in the presence of a lower production of their own endogenous anti-inflammatory interleukin-10. These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required. (Cancer Epidemiol Biomarkers Prev 2005;14(7):1613 – 8)" @default.
• W2913596162 created "2019-02-21" @default.
• W2913596162 creator A5004200935 @default.
• W2913596162 creator A5049801307 @default.
• W2913596162 creator A5064434034 @default.
• W2913596162 creator A5085045412 @default.
• W2913596162 creator A5089314192 @default.
• W2913596162 date "2004-04-01" @default.
• W2913596162 modified "2023-09-23" @default.
• W2913596162 title "The Role of Cytokine Gene Polymorphisms in Colorectal Cancer and Their Interaction with Aspirin Use in the Northeast of Scotland" @default.
• W2913596162 cites W1819074277 @default.
• W2913596162 cites W1965341361 @default.
• W2913596162 cites W1965684211 @default.
• W2913596162 cites W1971370481 @default.
• W2913596162 cites W1974938982 @default.
• W2913596162 cites W1992945893 @default.
• W2913596162 cites W2001046375 @default.
• W2913596162 cites W2001170097 @default.
• W2913596162 cites W2033503949 @default.
• W2913596162 cites W2036500213 @default.
• W2913596162 cites W2042474497 @default.
• W2913596162 cites W2049877091 @default.
• W2913596162 cites W2079517510 @default.
• W2913596162 cites W2084417526 @default.
• W2913596162 cites W2111275015 @default.
• W2913596162 cites W2115036588 @default.
• W2913596162 cites W2126352920 @default.
• W2913596162 cites W2138340454 @default.
• W2913596162 cites W2151324279 @default.
• W2913596162 cites W2155062341 @default.
• W2913596162 cites W2161074777 @default.
• W2913596162 cites W2163432183 @default.
• W2913596162 cites W2216494795 @default.
• W2913596162 cites W2910473757 @default.
• W2913596162 cites W2916192055 @default.
• W2913596162 hasPublicationYear "2004" @default.
• W2913596162 type Work @default.
• W2913596162 sameAs 2913596162 @default.
• W2913596162 citedByCount "0" @default.
• W2913596162 crossrefType "journal-article" @default.
• W2913596162 hasAuthorship W2913596162A5004200935 @default.
• W2913596162 hasAuthorship W2913596162A5049801307 @default.
• W2913596162 hasAuthorship W2913596162A5064434034 @default.
• W2913596162 hasAuthorship W2913596162A5085045412 @default.
• W2913596162 hasAuthorship W2913596162A5089314192 @default.
• W2913596162 hasConcept C104317684 @default.
• W2913596162 hasConcept C121608353 @default.
• W2913596162 hasConcept C126322002 @default.
• W2913596162 hasConcept C135763542 @default.
• W2913596162 hasConcept C143998085 @default.
• W2913596162 hasConcept C146304588 @default.
• W2913596162 hasConcept C156957248 @default.
• W2913596162 hasConcept C164027704 @default.
• W2913596162 hasConcept C180754005 @default.
• W2913596162 hasConcept C181199279 @default.
• W2913596162 hasConcept C203014093 @default.
• W2913596162 hasConcept C2776914184 @default.
• W2913596162 hasConcept C2777628954 @default.
• W2913596162 hasConcept C2779689624 @default.
• W2913596162 hasConcept C526805850 @default.
• W2913596162 hasConcept C54355233 @default.
• W2913596162 hasConcept C55493867 @default.
• W2913596162 hasConcept C71924100 @default.
• W2913596162 hasConcept C86803240 @default.
• W2913596162 hasConceptScore W2913596162C104317684 @default.
• W2913596162 hasConceptScore W2913596162C121608353 @default.
• W2913596162 hasConceptScore W2913596162C126322002 @default.
• W2913596162 hasConceptScore W2913596162C135763542 @default.
• W2913596162 hasConceptScore W2913596162C143998085 @default.
• W2913596162 hasConceptScore W2913596162C146304588 @default.
• W2913596162 hasConceptScore W2913596162C156957248 @default.
• W2913596162 hasConceptScore W2913596162C164027704 @default.
• W2913596162 hasConceptScore W2913596162C180754005 @default.
• W2913596162 hasConceptScore W2913596162C181199279 @default.
• W2913596162 hasConceptScore W2913596162C203014093 @default.
• W2913596162 hasConceptScore W2913596162C2776914184 @default.
• W2913596162 hasConceptScore W2913596162C2777628954 @default.
• W2913596162 hasConceptScore W2913596162C2779689624 @default.
• W2913596162 hasConceptScore W2913596162C526805850 @default.
• W2913596162 hasConceptScore W2913596162C54355233 @default.
• W2913596162 hasConceptScore W2913596162C55493867 @default.
• W2913596162 hasConceptScore W2913596162C71924100 @default.
• W2913596162 hasConceptScore W2913596162C86803240 @default.
• W2913596162 hasOpenAccess W2913596162 @default.
• W2913596162 hasRelatedWork W1979307143 @default.
• W2913596162 hasRelatedWork W2013932091 @default.
• W2913596162 hasRelatedWork W2018958047 @default.
• W2913596162 hasRelatedWork W2024432807 @default.
• W2913596162 hasRelatedWork W2042235166 @default.
• W2913596162 hasRelatedWork W2049500773 @default.
• W2913596162 hasRelatedWork W2062770593 @default.
• W2913596162 hasRelatedWork W2105364069 @default.
• W2913596162 hasRelatedWork W2105649938 @default.
• W2913596162 hasRelatedWork W2143666435 @default.
• W2913596162 hasRelatedWork W2145711433 @default.
• W2913596162 hasRelatedWork W2317799767 @default.
• W2913596162 hasRelatedWork W2324299588 @default.
• W2913596162 hasRelatedWork W2327282327 @default.
• W2913596162 hasRelatedWork W2576722945 @default.
• W2913596162 hasRelatedWork W2587893779 @default.

• next