FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913596528> ?p ?o ?g. }

• W2913596528 endingPage "1519" @default.
• W2913596528 startingPage "1507" @default.
• W2913596528 abstract "Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even become hyperprogressors. To investigate how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7 breast cancer cells with antigen-specific CD8+ T cells in which lytic granules had been destroyed by pretreatment with Concanamycin A. Gene expression analysis after coculture revealed simultaneous induction of PD-L1, IDO1, CEACAM1, and further immunoregulatory checkpoints in breast cancer cells. Strikingly, we further observed gene signatures characteristic for dedifferentiation and acquisition of pluripotency markers including Yamanaka factors. Cognate interaction with nonlytic CD8+ T cells also increased the proportion of stem cell-like cancer cells in a cell-to-cell contact- or (at least) proximity-dependent manner in various cell lines and in primary breast cancer cell cultures; this induction of stem cell-like properties was confirmed by enhanced tumor-forming capacity in immunodeficient mice. Resulting tumors were characterized by enhanced cell density, higher proliferation rates, and increased propensity for lymphoid metastasis. These findings describe a widely underappreciated pathway for immune escape, namely immune-mediated dedifferentiation of breast cancer cells, which is associated with profound changes in gene expression and cellular behavior. As the enhanced malignant potential of cancer cells after nonlytic cognate interactions with CD8+ T cells enables increased tumor growth and metastasis in BALB/cnu/nu mice, the described mechanism may provide a possible explanation for the clinical phenomenon of hyperprogression in response to unsuccessful immunotherapy. SIGNIFICANCE: This study shows that ineffective immune responses not only fail to clear a malignancy, but can also activate pathways in cancer cells that promote stemness and tumor-seeding capacity." @default.
• W2913596528 created "2019-02-21" @default.
• W2913596528 creator A5017254542 @default.
• W2913596528 creator A5018665647 @default.
• W2913596528 creator A5024765436 @default.
• W2913596528 creator A5028397596 @default.
• W2913596528 creator A5032460459 @default.
• W2913596528 creator A5047901338 @default.
• W2913596528 creator A5054102321 @default.
• W2913596528 creator A5055425144 @default.
• W2913596528 creator A5055821828 @default.
• W2913596528 creator A5057393976 @default.
• W2913596528 creator A5067944437 @default.
• W2913596528 creator A5074825799 @default.
• W2913596528 creator A5077445911 @default.
• W2913596528 creator A5077789430 @default.
• W2913596528 creator A5078888703 @default.
• W2913596528 creator A5081473975 @default.
• W2913596528 creator A5084080696 @default.
• W2913596528 creator A5084897568 @default.
• W2913596528 creator A5087780010 @default.
• W2913596528 date "2019-04-01" @default.
• W2913596528 modified "2023-10-18" @default.
• W2913596528 title "Cognate Nonlytic Interactions between CD8+ T Cells and Breast Cancer Cells Induce Cancer Stem Cell–like Properties" @default.
• W2913596528 cites W1896351481 @default.
• W2913596528 cites W1901777138 @default.
• W2913596528 cites W1931518331 @default.
• W2913596528 cites W1943839210 @default.
• W2913596528 cites W1963913686 @default.
• W2913596528 cites W1967096085 @default.
• W2913596528 cites W1973251492 @default.
• W2913596528 cites W1977355512 @default.
• W2913596528 cites W1987589866 @default.
• W2913596528 cites W1987636506 @default.
• W2913596528 cites W1996014355 @default.
• W2913596528 cites W1996344455 @default.
• W2913596528 cites W2008322756 @default.
• W2913596528 cites W2012120883 @default.
• W2913596528 cites W2020914260 @default.
• W2913596528 cites W2023323747 @default.
• W2913596528 cites W2023427658 @default.
• W2913596528 cites W2025457001 @default.
• W2913596528 cites W2028433016 @default.
• W2913596528 cites W2039123767 @default.
• W2913596528 cites W2040401602 @default.
• W2913596528 cites W2050558251 @default.
• W2913596528 cites W2051741566 @default.
• W2913596528 cites W2056298287 @default.
• W2913596528 cites W2057005548 @default.
• W2913596528 cites W2057893793 @default.
• W2913596528 cites W2058763255 @default.
• W2913596528 cites W2065514217 @default.
• W2913596528 cites W2066236445 @default.
• W2913596528 cites W2080359951 @default.
• W2913596528 cites W2098023402 @default.
• W2913596528 cites W2117692326 @default.
• W2913596528 cites W2118471749 @default.
• W2913596528 cites W2120656656 @default.
• W2913596528 cites W2125987139 @default.
• W2913596528 cites W2142210663 @default.
• W2913596528 cites W2152061559 @default.
• W2913596528 cites W2160834915 @default.
• W2913596528 cites W2160888498 @default.
• W2913596528 cites W2166666333 @default.
• W2913596528 cites W2214074259 @default.
• W2913596528 cites W2259938310 @default.
• W2913596528 cites W2554618897 @default.
• W2913596528 cites W2558219863 @default.
• W2913596528 cites W2601621622 @default.
• W2913596528 cites W2652151562 @default.
• W2913596528 cites W2673825361 @default.
• W2913596528 doi "https://doi.org/10.1158/0008-5472.can-18-0387" @default.
• W2913596528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692216" @default.
• W2913596528 hasPublicationYear "2019" @default.
• W2913596528 type Work @default.
• W2913596528 sameAs 2913596528 @default.
• W2913596528 citedByCount "29" @default.
• W2913596528 countsByYear W29135965282019 @default.
• W2913596528 countsByYear W29135965282020 @default.
• W2913596528 countsByYear W29135965282021 @default.
• W2913596528 countsByYear W29135965282022 @default.
• W2913596528 countsByYear W29135965282023 @default.
• W2913596528 crossrefType "journal-article" @default.
• W2913596528 hasAuthorship W2913596528A5017254542 @default.
• W2913596528 hasAuthorship W2913596528A5018665647 @default.
• W2913596528 hasAuthorship W2913596528A5024765436 @default.
• W2913596528 hasAuthorship W2913596528A5028397596 @default.
• W2913596528 hasAuthorship W2913596528A5032460459 @default.
• W2913596528 hasAuthorship W2913596528A5047901338 @default.
• W2913596528 hasAuthorship W2913596528A5054102321 @default.
• W2913596528 hasAuthorship W2913596528A5055425144 @default.
• W2913596528 hasAuthorship W2913596528A5055821828 @default.
• W2913596528 hasAuthorship W2913596528A5057393976 @default.
• W2913596528 hasAuthorship W2913596528A5067944437 @default.
• W2913596528 hasAuthorship W2913596528A5074825799 @default.
• W2913596528 hasAuthorship W2913596528A5077445911 @default.
• W2913596528 hasAuthorship W2913596528A5077789430 @default.
• W2913596528 hasAuthorship W2913596528A5078888703 @default.

• next