Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913618568> ?p ?o ?g. }
- W2913618568 endingPage "722" @default.
- W2913618568 startingPage "722" @default.
- W2913618568 abstract "Mixed lineage kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated. We identified that MLK3 tightly associates with an oncogene, PAK1. Mammalian PAK1 being a Ste20 (MAP4K) member, we tested whether it is an upstream regulator of MLK3. In contrast to our hypothesis, MLK3 activated PAK1 kinase activity directly, as well as in the cells. Although, MLK3 can phosphorylate PAK1 on Ser133 and Ser204 sites, PAK1S133A mutant is constitutively active, whereas, PAK1S204A is not activated by MLK3. Stable overexpression of PAK1S204A in breast cancer cells, impedes migration, invasion, and NFĸB activity. In vivo breast cancer cell tumorigenesis is significantly reduced in tumors expressing PAK1S204A mutant. These results suggest that mammalian PAK1 does not act as a MAP4K and MLK3-induced direct activation of PAK1 plays a key role in breast cancer tumorigenesis." @default.
- W2913618568 created "2019-02-21" @default.
- W2913618568 creator A5038930717 @default.
- W2913618568 creator A5044411309 @default.
- W2913618568 creator A5046360981 @default.
- W2913618568 creator A5049497627 @default.
- W2913618568 creator A5059546399 @default.
- W2913618568 creator A5059671953 @default.
- W2913618568 creator A5061500801 @default.
- W2913618568 creator A5079175978 @default.
- W2913618568 creator A5081839578 @default.
- W2913618568 creator A5089191106 @default.
- W2913618568 date "2019-09-17" @default.
- W2913618568 modified "2023-10-05" @default.
- W2913618568 title "Correction: Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1" @default.
- W2913618568 cites W1485140225 @default.
- W2913618568 cites W1539290896 @default.
- W2913618568 cites W1918275087 @default.
- W2913618568 cites W1964579181 @default.
- W2913618568 cites W1979400580 @default.
- W2913618568 cites W1980516263 @default.
- W2913618568 cites W1987134040 @default.
- W2913618568 cites W1998199805 @default.
- W2913618568 cites W1999826370 @default.
- W2913618568 cites W2009461629 @default.
- W2913618568 cites W2009906545 @default.
- W2913618568 cites W2016977803 @default.
- W2913618568 cites W2020466484 @default.
- W2913618568 cites W2027005796 @default.
- W2913618568 cites W2035394056 @default.
- W2913618568 cites W2037312364 @default.
- W2913618568 cites W2040567131 @default.
- W2913618568 cites W2050563501 @default.
- W2913618568 cites W2054353869 @default.
- W2913618568 cites W2054481493 @default.
- W2913618568 cites W2070190928 @default.
- W2913618568 cites W2080421196 @default.
- W2913618568 cites W2081972226 @default.
- W2913618568 cites W2092529209 @default.
- W2913618568 cites W2094458603 @default.
- W2913618568 cites W2098301815 @default.
- W2913618568 cites W2102787965 @default.
- W2913618568 cites W2104453682 @default.
- W2913618568 cites W2109309944 @default.
- W2913618568 cites W2114136380 @default.
- W2913618568 cites W2114207292 @default.
- W2913618568 cites W2125708696 @default.
- W2913618568 cites W2126376309 @default.
- W2913618568 cites W2131564236 @default.
- W2913618568 cites W2132847489 @default.
- W2913618568 cites W2136499331 @default.
- W2913618568 cites W2150866920 @default.
- W2913618568 cites W2155201844 @default.
- W2913618568 cites W2170564629 @default.
- W2913618568 cites W2274038956 @default.
- W2913618568 cites W2284592103 @default.
- W2913618568 cites W2514674691 @default.
- W2913618568 cites W2613083354 @default.
- W2913618568 cites W2621792783 @default.
- W2913618568 cites W2766710027 @default.
- W2913618568 cites W2790805946 @default.
- W2913618568 doi "https://doi.org/10.1038/s41388-019-1011-3" @default.
- W2913618568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7568686" @default.
- W2913618568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31530933" @default.
- W2913618568 hasPublicationYear "2019" @default.
- W2913618568 type Work @default.
- W2913618568 sameAs 2913618568 @default.
- W2913618568 citedByCount "7" @default.
- W2913618568 countsByYear W29136185682020 @default.
- W2913618568 countsByYear W29136185682021 @default.
- W2913618568 countsByYear W29136185682022 @default.
- W2913618568 countsByYear W29136185682023 @default.
- W2913618568 crossrefType "journal-article" @default.
- W2913618568 hasAuthorship W2913618568A5038930717 @default.
- W2913618568 hasAuthorship W2913618568A5044411309 @default.
- W2913618568 hasAuthorship W2913618568A5046360981 @default.
- W2913618568 hasAuthorship W2913618568A5049497627 @default.
- W2913618568 hasAuthorship W2913618568A5059546399 @default.
- W2913618568 hasAuthorship W2913618568A5059671953 @default.
- W2913618568 hasAuthorship W2913618568A5061500801 @default.
- W2913618568 hasAuthorship W2913618568A5079175978 @default.
- W2913618568 hasAuthorship W2913618568A5081839578 @default.
- W2913618568 hasAuthorship W2913618568A5089191106 @default.
- W2913618568 hasBestOaLocation W29136185681 @default.
- W2913618568 hasConcept C104317684 @default.
- W2913618568 hasConcept C11960822 @default.
- W2913618568 hasConcept C121608353 @default.
- W2913618568 hasConcept C184235292 @default.
- W2913618568 hasConcept C2776817793 @default.
- W2913618568 hasConcept C502942594 @default.
- W2913618568 hasConcept C51853150 @default.
- W2913618568 hasConcept C54355233 @default.
- W2913618568 hasConcept C55493867 @default.
- W2913618568 hasConcept C555283112 @default.
- W2913618568 hasConcept C82495950 @default.
- W2913618568 hasConcept C86803240 @default.
- W2913618568 hasConcept C95444343 @default.
- W2913618568 hasConcept C97029542 @default.