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• W2913622377 abstract "Purpose . To compare the intraocular cytokine and chemokine profiles in patients with acute primary acquired ocular toxoplasmosis (pOT) or recurrent ocular toxoplasmosis (rOT) and to correlate them with their clinical characteristics. Methods . Aqueous humor samples were collected from 62 consecutive patients (21 pOT, 30 rOT, and 11 noninfected controls) and analyzed by multiplex assay. Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (T h 1, T h 2, and T h 17), and clinical characteristics. In all OT patients, the clinical diagnosis of either pOT or rOT was confirmed by positive intraocular Goldmann/Witmer-Desmonts coefficient. Correlations were assessed between a preselected panel of immune mediators and the clinical characteristics of OT. Results . In pOT patients, increased levels of IL-2, IFN- γ , TNF- α , IL-15, IL-4, IL-5, IL-9, IL-13, IL-17, IL-1R α , IL-6, IL-1 β , and chemokines MIP-1 α , MIP-1 β , IP-10, Eotaxin, IL-8, RANTES, PDGF-bb, GM-CSF, G-CSF, and MCP-1 were found in comparison to those in controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). Patients with rOT showed elevated levels of IL-2, IFN- γ , TNF- α , IL-15, IL-4, IL-5, IL-9, IL-17, IL-1R α , IL-6, IL-1 β , and chemokines MIP-1 α , IP-10, Eotaxin, IL-8, RANTES, PDGF-bb, G-CSF, and MCP-1 compared to controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). In addition, IL-7 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.028</mml:mn></mml:math>) differed between pOT and rOT; IL-9 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.054</mml:mn></mml:math>) and IL-13 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.051</mml:mn></mml:math>) showed a tendency of higher concentration in pOT than in rOT. A negative correlation was found between IL-7 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.017</mml:mn></mml:math>) as well as IL-9 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.008</mml:mn></mml:math>) and the number of recurrences. Cytokine ratios showed no difference between pOT and rOT, indicating a dominant T h 1-type response in both infectious groups. Moreover, a positive correlation was detected between IL-7, VEGF, IL-13 and age at aqueous humor sampling (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>). Conclusions . This study for the first time shows subtle differences between the intraocular cytokine profiles in patients with either acute pOT or rOT." @default.
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• W2913622377 date "2019-02-17" @default.
• W2913622377 modified "2023-10-14" @default.
• W2913622377 title "Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis" @default.
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• W2913622377 doi "https://doi.org/10.1155/2019/9356728" @default.
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