FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913644237> ?p ?o ?g. }

• W2913644237 endingPage "e0211281" @default.
• W2913644237 startingPage "e0211281" @default.
• W2913644237 abstract "Diabetes is a very strong predictor of chronic systemic vascular diseases and acute cardiovascular events. Recently, associations between metabolic disorders and pulmonary hypertension have also been reported in both humans and animal models. In order to get some further insight into the relationship of pulmonary hypertension with obesity, insulin resistance and hyperglycemia, herein we have used the Zucker diabetic fatty rats (ZDF/clr-lepr fa) at 20 weeks fed a standard diet and compared to their lean Zucker littermates (ZL). ZDF rats were obese, had elevated plasma glucose levels and insulin resistance, i.e. a clinically relevant model of type 2 diabetes. They presented elevated systolic, diastolic and mean pulmonary arterial pressures and a parallel increase in the Fulton index. Systemic arterial pressures were also increased but the left ventricle plus septum weight was similar in both groups and the heart rate was reduced. Wall media thickening was observed in the small pulmonary arteries from the ZDF rats. Isolated pulmonary arteries mounted in a wire myograph showed similar vasoconstrictor responses to phenylephrine and 5-HT and similar responses to the endothelium-dependent vasodilator acetylcholine. However, the iNOS inhibitor 1400W enhanced the vasoconstrictor responses in ZDF but not in ZL rats. The protein expression of eNOS and iNOS was not significantly different in the lungs of the two groups. The lung expression of Bmpr2 mRNA was downregulated. However, the mRNA expression of Kcna5, Kcnk3, Kcnq1, Kcnq4 or Kcnq5, which encode for the potassium channels Kv1.5, TASK-1, Kv7.1, Kv7.4 and Kv7.5, respectively, was similar in ZL and ZDF rats. In conclusion, ZDF rats show increased pulmonary arterial pressure, right ventricular hypertrophy, pulmonary arterial medial thickening and downregulated lung Bmpr2 despite leptin resistance. These changes were mild but are consistent with the view that diabetes is a risk factor for pulmonary hypertension." @default.
• W2913644237 created "2019-02-21" @default.
• W2913644237 creator A5002973300 @default.
• W2913644237 creator A5003207273 @default.
• W2913644237 creator A5005785178 @default.
• W2913644237 creator A5028626530 @default.
• W2913644237 creator A5042390976 @default.
• W2913644237 creator A5071640634 @default.
• W2913644237 creator A5080759094 @default.
• W2913644237 creator A5084520570 @default.
• W2913644237 creator A5088780059 @default.
• W2913644237 creator A5091585058 @default.
• W2913644237 date "2019-01-28" @default.
• W2913644237 modified "2023-10-18" @default.
• W2913644237 title "Elevated pulmonary arterial pressure in Zucker diabetic fatty rats" @default.
• W2913644237 cites W1866413456 @default.
• W2913644237 cites W1965055751 @default.
• W2913644237 cites W1968726376 @default.
• W2913644237 cites W1971915589 @default.
• W2913644237 cites W1974884938 @default.
• W2913644237 cites W1981010609 @default.
• W2913644237 cites W1991064387 @default.
• W2913644237 cites W2001385061 @default.
• W2913644237 cites W2013401002 @default.
• W2913644237 cites W2021817221 @default.
• W2913644237 cites W2023749078 @default.
• W2913644237 cites W2050650371 @default.
• W2913644237 cites W2060430036 @default.
• W2913644237 cites W2088829415 @default.
• W2913644237 cites W2089786994 @default.
• W2913644237 cites W2093257770 @default.
• W2913644237 cites W2095314259 @default.
• W2913644237 cites W2099137703 @default.
• W2913644237 cites W2103157248 @default.
• W2913644237 cites W2105676857 @default.
• W2913644237 cites W2109889741 @default.
• W2913644237 cites W2112008193 @default.
• W2913644237 cites W2114059400 @default.
• W2913644237 cites W2114846724 @default.
• W2913644237 cites W2118323422 @default.
• W2913644237 cites W2118452945 @default.
• W2913644237 cites W2120105455 @default.
• W2913644237 cites W2122851556 @default.
• W2913644237 cites W2131264643 @default.
• W2913644237 cites W2135935974 @default.
• W2913644237 cites W2153311231 @default.
• W2913644237 cites W2168420558 @default.
• W2913644237 cites W2172065160 @default.
• W2913644237 cites W2282364919 @default.
• W2913644237 cites W2405769729 @default.
• W2913644237 cites W2460081016 @default.
• W2913644237 cites W2518837956 @default.
• W2913644237 cites W2623069019 @default.
• W2913644237 cites W2800181551 @default.
• W2913644237 cites W4301775428 @default.
• W2913644237 doi "https://doi.org/10.1371/journal.pone.0211281" @default.
• W2913644237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6349336" @default.
• W2913644237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30689673" @default.
• W2913644237 hasPublicationYear "2019" @default.
• W2913644237 type Work @default.
• W2913644237 sameAs 2913644237 @default.
• W2913644237 citedByCount "10" @default.
• W2913644237 countsByYear W29136442372019 @default.
• W2913644237 countsByYear W29136442372020 @default.
• W2913644237 countsByYear W29136442372021 @default.
• W2913644237 countsByYear W29136442372022 @default.
• W2913644237 crossrefType "journal-article" @default.
• W2913644237 hasAuthorship W2913644237A5002973300 @default.
• W2913644237 hasAuthorship W2913644237A5003207273 @default.
• W2913644237 hasAuthorship W2913644237A5005785178 @default.
• W2913644237 hasAuthorship W2913644237A5028626530 @default.
• W2913644237 hasAuthorship W2913644237A5042390976 @default.
• W2913644237 hasAuthorship W2913644237A5071640634 @default.
• W2913644237 hasAuthorship W2913644237A5080759094 @default.
• W2913644237 hasAuthorship W2913644237A5084520570 @default.
• W2913644237 hasAuthorship W2913644237A5088780059 @default.
• W2913644237 hasAuthorship W2913644237A5091585058 @default.
• W2913644237 hasBestOaLocation W29136442371 @default.
• W2913644237 hasConcept C120770815 @default.
• W2913644237 hasConcept C126322002 @default.
• W2913644237 hasConcept C134018914 @default.
• W2913644237 hasConcept C164705383 @default.
• W2913644237 hasConcept C2777180221 @default.
• W2913644237 hasConcept C2777391703 @default.
• W2913644237 hasConcept C2777622882 @default.
• W2913644237 hasConcept C2777952589 @default.
• W2913644237 hasConcept C2778326061 @default.
• W2913644237 hasConcept C2778921608 @default.
• W2913644237 hasConcept C2779306644 @default.
• W2913644237 hasConcept C2779941686 @default.
• W2913644237 hasConcept C2780930700 @default.
• W2913644237 hasConcept C519581460 @default.
• W2913644237 hasConcept C555293320 @default.
• W2913644237 hasConcept C58245268 @default.
• W2913644237 hasConcept C71924100 @default.
• W2913644237 hasConcept C84393581 @default.
• W2913644237 hasConceptScore W2913644237C120770815 @default.
• W2913644237 hasConceptScore W2913644237C126322002 @default.

• next