Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913648927> ?p ?o ?g. }
- W2913648927 endingPage "4470" @default.
- W2913648927 startingPage "4462" @default.
- W2913648927 abstract "Significance The hallmark of protective immunity to infection and vaccination is the generation of long-lived plasma cells (LLPCs) secreting high-affinity antibodies. T follicular helper cells (Tfh) must be retained within specialized germinal center (GC) structures to provide essential help to B cells for LLPC generation. How such Tfh GC accumulation is sustained is unclear. We identify an ECM:α V integrin axis in the control of the GC reaction. In the absence of T cell α V integrins, Tfh are generated and can support early B cell responses but fail to accumulate within the GC, resulting in a striking absence of LLPCs. Targeting α V integrins may enable novel therapeutic control of Tfh GC numbers to boost immunity or mitigate Ab-mediated autoimmune pathology." @default.
- W2913648927 created "2019-02-21" @default.
- W2913648927 creator A5000678909 @default.
- W2913648927 creator A5008998257 @default.
- W2913648927 creator A5026004941 @default.
- W2913648927 creator A5028607361 @default.
- W2913648927 creator A5061605555 @default.
- W2913648927 creator A5086036223 @default.
- W2913648927 date "2019-02-15" @default.
- W2913648927 modified "2023-10-18" @default.
- W2913648927 title "Pivotal role for α <sub>V</sub> integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation" @default.
- W2913648927 cites W118250301 @default.
- W2913648927 cites W1584463243 @default.
- W2913648927 cites W1672365164 @default.
- W2913648927 cites W1681312898 @default.
- W2913648927 cites W1702319215 @default.
- W2913648927 cites W1901606394 @default.
- W2913648927 cites W1917974963 @default.
- W2913648927 cites W1977237743 @default.
- W2913648927 cites W1983304157 @default.
- W2913648927 cites W1983713616 @default.
- W2913648927 cites W1988376910 @default.
- W2913648927 cites W1989134497 @default.
- W2913648927 cites W1990297263 @default.
- W2913648927 cites W1999927488 @default.
- W2913648927 cites W1999985136 @default.
- W2913648927 cites W2001634461 @default.
- W2913648927 cites W2004096270 @default.
- W2913648927 cites W2006493954 @default.
- W2913648927 cites W2009852881 @default.
- W2913648927 cites W2013262178 @default.
- W2913648927 cites W2014113929 @default.
- W2913648927 cites W2016054852 @default.
- W2913648927 cites W2035183057 @default.
- W2913648927 cites W2046517086 @default.
- W2913648927 cites W2046752806 @default.
- W2913648927 cites W2048175444 @default.
- W2913648927 cites W2050912169 @default.
- W2913648927 cites W2053849689 @default.
- W2913648927 cites W2057798678 @default.
- W2913648927 cites W2059033421 @default.
- W2913648927 cites W2061891141 @default.
- W2913648927 cites W2066489069 @default.
- W2913648927 cites W2071380288 @default.
- W2913648927 cites W2074109173 @default.
- W2913648927 cites W2074309287 @default.
- W2913648927 cites W2079633218 @default.
- W2913648927 cites W2089723196 @default.
- W2913648927 cites W2091748474 @default.
- W2913648927 cites W2096880157 @default.
- W2913648927 cites W2098130194 @default.
- W2913648927 cites W2109829361 @default.
- W2913648927 cites W2118362622 @default.
- W2913648927 cites W2123130879 @default.
- W2913648927 cites W2129509656 @default.
- W2913648927 cites W2131090561 @default.
- W2913648927 cites W2136471260 @default.
- W2913648927 cites W2136671639 @default.
- W2913648927 cites W2137446997 @default.
- W2913648927 cites W2158279347 @default.
- W2913648927 cites W2162462569 @default.
- W2913648927 cites W2168952458 @default.
- W2913648927 cites W2239291357 @default.
- W2913648927 cites W2295020433 @default.
- W2913648927 cites W2338738911 @default.
- W2913648927 cites W2495939528 @default.
- W2913648927 cites W2511881100 @default.
- W2913648927 cites W2521741241 @default.
- W2913648927 cites W2527013454 @default.
- W2913648927 cites W2533714535 @default.
- W2913648927 cites W2578371477 @default.
- W2913648927 cites W2596748283 @default.
- W2913648927 cites W2596831859 @default.
- W2913648927 cites W2605956581 @default.
- W2913648927 cites W2611430380 @default.
- W2913648927 cites W4230977854 @default.
- W2913648927 cites W4246504300 @default.
- W2913648927 cites W54523488 @default.
- W2913648927 doi "https://doi.org/10.1073/pnas.1809329116" @default.
- W2913648927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6410787" @default.
- W2913648927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770452" @default.
- W2913648927 hasPublicationYear "2019" @default.
- W2913648927 type Work @default.
- W2913648927 sameAs 2913648927 @default.
- W2913648927 citedByCount "13" @default.
- W2913648927 countsByYear W29136489272021 @default.
- W2913648927 countsByYear W29136489272022 @default.
- W2913648927 countsByYear W29136489272023 @default.
- W2913648927 crossrefType "journal-article" @default.
- W2913648927 hasAuthorship W2913648927A5000678909 @default.
- W2913648927 hasAuthorship W2913648927A5008998257 @default.
- W2913648927 hasAuthorship W2913648927A5026004941 @default.
- W2913648927 hasAuthorship W2913648927A5028607361 @default.
- W2913648927 hasAuthorship W2913648927A5061605555 @default.
- W2913648927 hasAuthorship W2913648927A5086036223 @default.
- W2913648927 hasBestOaLocation W29136489271 @default.
- W2913648927 hasConcept C1491633281 @default.
- W2913648927 hasConcept C159654299 @default.