Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913653817> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2913653817 abstract "Background: The process of laryngoscopy and endotracheal intubation is usually associated with exaggerated haemodynamic response. In extreme cases this response may result in myocardial ischaemia, cardiac failure, increase in intracranial pressure and intracranial haemorrhage. Hence our prospective randomized double blinded placebo control study was designed to observe the effect of pregabalin in attenuating this haemodynamic response. Method: In this study, 100 adult patients of ASAPS I and II undergoing elective laparoscopic cholecystectomy were included. The patients were randomly allocated into two groups, group P received 150mg oral pregabalin and group C received similarly looking B complex capsules one hour before the surgery. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were observed. Sedation score was assessed using Ramsay sedation scale. Results: We observed an increase in all the haemodynamic parameters in both the groups. The percentage change in HR and MAP from baseline at one-minute following intubation was +33% and +28.5% in control group compared to +14% and +3% in pregabalin group. Similarly, the percentage change at five minutes after carboperitoneum was +24% and +26% in control group compared to +4% and +0.8% in pregabalin group. This difference was statistically significant with P value Conclusion: Oral pregabalin in a dose of 150mg one hour before the surgery is a safe and effective premedicant in attenuating pressor response to laryngoscopy, intubation and laparoscopy. It also produces good sedation without any adverse effects." @default.
- W2913653817 created "2019-02-21" @default.
- W2913653817 creator A5047409135 @default.
- W2913653817 creator A5054200064 @default.
- W2913653817 creator A5085596643 @default.
- W2913653817 date "2019-02-06" @default.
- W2913653817 modified "2023-09-24" @default.
- W2913653817 title "Study to determine the effect of oral pregabalin premedication on haemodynamic response to laryngoscopy, intubation and carbon dioxide insufflation during laparoscopic cholecystectomy" @default.
- W2913653817 doi "https://doi.org/10.4038/slja.v27i1.8341" @default.
- W2913653817 hasPublicationYear "2019" @default.
- W2913653817 type Work @default.
- W2913653817 sameAs 2913653817 @default.
- W2913653817 citedByCount "0" @default.
- W2913653817 crossrefType "journal-article" @default.
- W2913653817 hasAuthorship W2913653817A5047409135 @default.
- W2913653817 hasAuthorship W2913653817A5054200064 @default.
- W2913653817 hasAuthorship W2913653817A5085596643 @default.
- W2913653817 hasBestOaLocation W29136538171 @default.
- W2913653817 hasConcept C126322002 @default.
- W2913653817 hasConcept C141071460 @default.
- W2913653817 hasConcept C178853913 @default.
- W2913653817 hasConcept C2776452961 @default.
- W2913653817 hasConcept C2776468701 @default.
- W2913653817 hasConcept C2776814716 @default.
- W2913653817 hasConcept C2776888792 @default.
- W2913653817 hasConcept C2777953023 @default.
- W2913653817 hasConcept C2778029997 @default.
- W2913653817 hasConcept C2778300832 @default.
- W2913653817 hasConcept C2778716859 @default.
- W2913653817 hasConcept C42219234 @default.
- W2913653817 hasConcept C71924100 @default.
- W2913653817 hasConcept C84393581 @default.
- W2913653817 hasConceptScore W2913653817C126322002 @default.
- W2913653817 hasConceptScore W2913653817C141071460 @default.
- W2913653817 hasConceptScore W2913653817C178853913 @default.
- W2913653817 hasConceptScore W2913653817C2776452961 @default.
- W2913653817 hasConceptScore W2913653817C2776468701 @default.
- W2913653817 hasConceptScore W2913653817C2776814716 @default.
- W2913653817 hasConceptScore W2913653817C2776888792 @default.
- W2913653817 hasConceptScore W2913653817C2777953023 @default.
- W2913653817 hasConceptScore W2913653817C2778029997 @default.
- W2913653817 hasConceptScore W2913653817C2778300832 @default.
- W2913653817 hasConceptScore W2913653817C2778716859 @default.
- W2913653817 hasConceptScore W2913653817C42219234 @default.
- W2913653817 hasConceptScore W2913653817C71924100 @default.
- W2913653817 hasConceptScore W2913653817C84393581 @default.
- W2913653817 hasLocation W29136538171 @default.
- W2913653817 hasOpenAccess W2913653817 @default.
- W2913653817 hasPrimaryLocation W29136538171 @default.
- W2913653817 hasRelatedWork W2091305423 @default.
- W2913653817 hasRelatedWork W2105047161 @default.
- W2913653817 hasRelatedWork W2109613253 @default.
- W2913653817 hasRelatedWork W2371230575 @default.
- W2913653817 hasRelatedWork W2620065506 @default.
- W2913653817 hasRelatedWork W2895858263 @default.
- W2913653817 hasRelatedWork W2913653817 @default.
- W2913653817 hasRelatedWork W3034882672 @default.
- W2913653817 hasRelatedWork W4223428555 @default.
- W2913653817 hasRelatedWork W2946010974 @default.
- W2913653817 isParatext "false" @default.
- W2913653817 isRetracted "false" @default.
- W2913653817 magId "2913653817" @default.
- W2913653817 workType "article" @default.