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- W2913656146 abstract "Abstract MicroRNAs (miRNA) are small noncoding oligoribonucleotides having potential of silencing/knocking out target genes by regulating posttranscriptional events of gene expression. Since many miRNAs have exhibited change in profile in disease conditions, researchers are attracted toward their role assignment in disease development and control, if any. With the finding that many miRNAs are associated with disease progression, this species of RNA has become an attractive target for therapy. The reestablishment of downregulated miRNAs or inhibition of overexpressed miRNAs to return in their usual state is the basis of miRNA-guided treatment. This chapter focuses on fundamentals of miRNA-based knocking out of target genes using nanocarriers, as they provide physical and biochemical stability to the unstable miRNAs and enhance their efficiency to perform. It also encompasses the recent tools of nonviral delivery, such as, polymer-, lipid-, metal/metal-oxides, and other nanoparticles for in vitro/in vivo transport of miRNA. The immunological responses, linked with the nanocarriers as well as miRNA, are also discussed along with challenges to efficient delivery and toxicity. The size, shape, charge, and surface properties of nanotransporters have also been illustrated, which need to be modified to ensure efficient as well as safe transport of the miRNAs in medical practice. It is anticipated that by overcoming the transport obstacles and with very good understanding of the effects like duration of gene silencing, miRNAs will effectively contribute in practical therapeutics in the near future." @default.
- W2913656146 created "2019-02-21" @default.
- W2913656146 creator A5034194890 @default.
- W2913656146 creator A5070710258 @default.
- W2913656146 creator A5087473918 @default.
- W2913656146 date "2019-01-01" @default.
- W2913656146 modified "2023-10-16" @default.
- W2913656146 title "Nanoparticles Mediated Gene Knockout Through miRNA Replacement" @default.
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