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• W2913664054 abstract "New microextraction techniques have been developed for sample preparation of azole drugs and penicillins in water, milk and biological samples prior to their liquid chromatographic determination. A microextraction method based on solid phase membrane tip extraction (SPMTE) incorporated with mesoporous silica, MCM-41, was developed for the determination of azole antifungal drugs, namely voriconazole (VRZ), ketoconazole (KTZ) and itraconazole (ITZ) in human plasma. Under the optimized conditions, the method demonstrated good linearity (r2 = 0.9958) over a concentration range of 60 - 8000 µg L-1 with low limits of detection in the range of 20 - 40 µg L-1. MCM-41-SPMTE required only minute amounts of adsorbent (3 mg) and desorption solvent (100 µL) and proved a successful extraction technique with high relative recoveries in the range of 82.5 - 111.0% for the analytes. MCM-41 was also employed as adsorbent in dispersive micro-solid phase extraction (D-µ-SPE) of six azole antifungal drugs including VRZ, KTZ, miconazole (MCZ), clotrimazole (CTZ), fluconazole (FLZ) and econazole (ECZ). The optimized D-µ- SPE was successfully applied to the determination of azole drugs in urine and human plasma. The method showed good linearity (r2 = 0.9900) over a concentration range of 0.1 - 10000 µg L-1, excellent limits of detection in the range of 0.001 - 1.500 µg L-1 and good relative recoveries in the range of 80.9 - 116.8%. A D-µ-SPE method incorporating new mesoporous carbon COU-2 as adsorbent was developed for the determination of three penicillins in water and milk samples. Under the optimized conditions, COU-2-D-µ-SPE showed excellent limits of detection in the range of 0.06 - 3.3 µg L-1 for oxacillin, cloxacillin and dicloxacillin with good linearity (r2 = 0.9992) in the concentration range of 0.1 - 5000 µg L-1 and good relative recoveries (80.3 - 113.6%). COU-2-D-µ-SPE is beneficial in terms of solvent saving, simplified analytical procedure and rapid extraction. The surface of COU-2 was further modified by functionalization with vinyl group to improve the extraction of target azole antifungal drugs by increasing the hydrophobicity of the adsorbent. Vinyl-COU-2 was used as adsorbent in D-µ-SPE (Vinyl-COU-2-D-µ-SPE) for the determination of azole antifungal drugs in water and biological samples. Excellent limits of detection (0.4 - 1.6 µg L-1) were obtained for KTZ and ITZ, respectively, with good linearity (r2 = 0.9959) in the concentration range of 1 - 400 µg L-1. The method provided high enrichment factors up to 92 with excellent relative recoveries in the range of 89.8 - 113.9% for both analytes. The developed microextraction techniques combined with liquid chromatography have proved to be simple, rapid and efficient with performances that are superior to those of conventional methods and suitable for the determination of azole drugs and penicillins in water, milk and biological samples." @default.
• W2913664054 created "2019-02-21" @default.
• W2913664054 creator A5064904878 @default.
• W2913664054 date "2014-06-01" @default.
• W2913664054 modified "2023-09-23" @default.
• W2913664054 title "New micro-solid phase extraction techniques based on mesoporous materials for selected antibiotic and antifungal agents" @default.
• W2913664054 cites W1485429264 @default.
• W2913664054 cites W1518223044 @default.
• W2913664054 cites W1526988727 @default.
• W2913664054 cites W153878259 @default.
• W2913664054 cites W1566547551 @default.
• W2913664054 cites W157973430 @default.
• W2913664054 cites W1579928054 @default.
• W2913664054 cites W1920514480 @default.
• W2913664054 cites W1964606720 @default.
• W2913664054 cites W1965945719 @default.
• W2913664054 cites W1966593503 @default.
• W2913664054 cites W1968174755 @default.
• W2913664054 cites W1968929736 @default.
• W2913664054 cites W1969220789 @default.
• W2913664054 cites W1970493049 @default.
• W2913664054 cites W1971155315 @default.
• W2913664054 cites W1971966881 @default.
• W2913664054 cites W1972121081 @default.
• W2913664054 cites W1972245384 @default.
• W2913664054 cites W1972836897 @default.
• W2913664054 cites W1976087426 @default.
• W2913664054 cites W1977289801 @default.
• W2913664054 cites W1977611067 @default.
• W2913664054 cites W1978102456 @default.
• W2913664054 cites W1978232308 @default.
• W2913664054 cites W1980176625 @default.
• W2913664054 cites W1981436185 @default.
• W2913664054 cites W1981940767 @default.
• W2913664054 cites W1982029099 @default.
• W2913664054 cites W1982179793 @default.
• W2913664054 cites W1982216664 @default.
• W2913664054 cites W1982349821 @default.
• W2913664054 cites W1983213442 @default.
• W2913664054 cites W1983243293 @default.
• W2913664054 cites W1983331554 @default.
• W2913664054 cites W1986709202 @default.
• W2913664054 cites W1987424298 @default.
• W2913664054 cites W1987973138 @default.
• W2913664054 cites W1988016868 @default.
• W2913664054 cites W1988297142 @default.
• W2913664054 cites W1988773096 @default.
• W2913664054 cites W1988899411 @default.
• W2913664054 cites W1989002059 @default.
• W2913664054 cites W1990095380 @default.
• W2913664054 cites W1990243392 @default.
• W2913664054 cites W1990695589 @default.
• W2913664054 cites W1992452652 @default.
• W2913664054 cites W1992675172 @default.
• W2913664054 cites W1993653546 @default.
• W2913664054 cites W1994903772 @default.
• W2913664054 cites W1995439505 @default.
• W2913664054 cites W1996937620 @default.
• W2913664054 cites W1998608212 @default.
• W2913664054 cites W1999534179 @default.
• W2913664054 cites W2000555900 @default.
• W2913664054 cites W2001156673 @default.
• W2913664054 cites W2001461207 @default.
• W2913664054 cites W2001473672 @default.
• W2913664054 cites W2001535293 @default.
• W2913664054 cites W2001699464 @default.
• W2913664054 cites W2003031458 @default.
• W2913664054 cites W2003812520 @default.
• W2913664054 cites W2005017007 @default.
• W2913664054 cites W2006551151 @default.
• W2913664054 cites W2007802356 @default.
• W2913664054 cites W2007982928 @default.
• W2913664054 cites W2008361065 @default.
• W2913664054 cites W2008706613 @default.
• W2913664054 cites W2009208662 @default.
• W2913664054 cites W2009752942 @default.
• W2913664054 cites W2010211017 @default.
• W2913664054 cites W2012750720 @default.
• W2913664054 cites W2016843707 @default.
• W2913664054 cites W2017349486 @default.
• W2913664054 cites W2017606328 @default.
• W2913664054 cites W2018597808 @default.
• W2913664054 cites W2019894998 @default.
• W2913664054 cites W2020942204 @default.
• W2913664054 cites W2025932520 @default.
• W2913664054 cites W2026912513 @default.
• W2913664054 cites W2028210618 @default.
• W2913664054 cites W2028588070 @default.
• W2913664054 cites W2028609463 @default.
• W2913664054 cites W2029377716 @default.
• W2913664054 cites W2029593210 @default.
• W2913664054 cites W2030644038 @default.
• W2913664054 cites W2032145790 @default.
• W2913664054 cites W2035019470 @default.
• W2913664054 cites W2035522180 @default.
• W2913664054 cites W2036473729 @default.
• W2913664054 cites W2036920581 @default.
• W2913664054 cites W2036993430 @default.
• W2913664054 cites W2037147751 @default.
• W2913664054 cites W2038792535 @default.

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